[Sun protection of human skin: from A to Z]
- PMID: 35146544
- DOI: 10.1007/s00105-022-04953-2
[Sun protection of human skin: from A to Z]
Abstract
Solar radiation contains about 6.8% ultraviolet (UV) radiation. UV radiation is still regarded as one of the most important risk factors for both nonmelanoma skin cancer (NMSC; predominantly basal cell carcinoma and squamous cell carcinoma) and malignant melanoma (MM). To avoid induction and persistence of UV-induced mutations, our skin is armed with an arsenal of endogenous protective mechanisms such as induction of cell cycle arrest, repair mechanisms, immunosurveillance and the initiation of various types of cell death. Exogenous sun protection includes a range of behaviors such as avoiding extensive sun exposure, wearing UV-proof clothing and appropriate application of topical sunscreens.
Ultraviolette (UV) Strahlung macht etwa 6,8 % der Sonnenstrahlung aus. Sie gilt als bedeutender Risikofaktor sowohl für nichtmelanozytären Hautkrebs (NMSC, vorwiegend Basalzellkarzinom und Plattenepithelkarzinom) als auch für das maligne Melanom (MM). Die Haut trägt durch endogene Schutzmechanismen wie Verzögerung der Zellteilung, Induktion von Reparaturmechanismen, Immunschutzmechanismen sowie die Einleitung verschiedener Formen des Zelltodes dazu bei, die Entstehung und Persistenz von UV-induzierten Mutationen zu reduzieren. Zum exogenen Sonnenschutz zählt man eine Reihe von Verhaltensweisen wie das Vermeiden starker Sonnenexposition, das Tragen von UV-undurchlässiger Kleidung sowie die Anwendung von Sonnenschutzmitteln.
Keywords: Climate change; Skin cancer; Sun protection; Sunscreen; Ultraviolet radiation.
© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
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