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Randomized Controlled Trial
. 2022 Feb 11;101(6):e28730.
doi: 10.1097/MD.0000000000028730.

Motivational interviewing retention counseling and adherence to early infant diagnostic HIV testing schedule in South Africa: The PAEDLINK randomized trial

Dorina Onoya  1 , Nelly Jinga  1 , Cornelius Nattey  1 , Constance Mongwenyana  1 , Sithabile Mngadi  1 , William B MacLeod  1   2 , Gayle Sherman  3
Affiliations
Randomized Controlled Trial

Motivational interviewing retention counseling and adherence to early infant diagnostic HIV testing schedule in South Africa: The PAEDLINK randomized trial

Dorina Onoya et al. Medicine (Baltimore). .

Erratum in

Abstract

Introduction: We report the PAEDLINK randomized trial results on the effect of motivational interviewing (MI) retention counseling on the adherence of postpartum women to the early infant diagnostic human immunodeficiency virus (HIV) testing schedule.

Methods: HIV positive women and their babies were enrolled 3 to 6 days after delivery at 4 midwife obstetric units in the Gauteng province of South Africa and randomized into (A) MI retention counseling and telephonic tracing, (B) biannual telephonic tracing, and (C) standard care. Mother-baby pairs were followed up for 18 months via medical records. The uptake of child HIV tests and maternal retention in the 0 to 6 and 7 to 18 month periods were modeled using Log-binomial regression.

Results: Overall, 501/711 enrolled mother-baby pairs received a second HIV polymerase chain reaction test by 6 months (70.0%, 70.5%, and 70.0% in groups A, B, and C, respectively). A higher proportion of intervention children (60.9%) were tested at 7 to 90 days than group B (48.1%, adjusted risk ratio [aRR] 0.8 for B vs A, 95% confidence interval [CI]: 0.7-0.9) and group C children (52.7%, aRR 0.9 for C vs A, 95% CI: 0.9-1.0). Child testing between 7 and 18-months was also higher in group A than C (10.7% A, vs 5.5% C, RR 2.0, 95% CI: 1.0-3.7). However, maternal retention was similar across groups, with 41.6% and 16.3% retained during the 0 to 6 and the 7 to 18-months periods, respectively.

Conclusion: MI retention counseling can reduce delays in the early infant diagnosis testing schedule for HIV-exposed infants. However, further support is necessary to maximize later HIV tests and maternal retention.

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Conflict of interest statement

The authors have no conflicts of interests to disclose.

Figures

Figure 1
Figure 1
CONSORT diagram of participant enrolment, randomization, and follow-up in the postpartum study. CONSORT = Consolidated Standards of Reporting Trials.
Figure 2
Figure 2
Map of ANC, childbirth, and postpartum care among the participating HIV positive mother. ANC = antenatal care, HIV = human immunodeficiency virus.
Figure 3
Figure 3
Uptake and timing of the second infant HIV PCR and 7 to 18 months HIV antibody test among HIV-exposed children by randomization group. HIV = human immunodeficiency virus, PCR = polymerase chain reaction.
See this image and copyright information in PMC

References

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