Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jun;8(2):139-147.
doi: 10.1007/s41030-022-00184-x. Epub 2022 Feb 11.

Cystic Fibrosis and Sleep Circadian Rhythms

Mariam Louis  1 , Peter Staiano  1 , Lavender Micalo  2 , Nauman Chaudary  3
Affiliations
Review

Cystic Fibrosis and Sleep Circadian Rhythms

Mariam Louis et al. Pulm Ther. 2022 Jun.

Abstract

Cystic fibrosis (CF) is due to a mutation in the cystic fibrosis transmembrane conductance regulator gene (CFTR), which leads to unusual water and chloride secretion across epithelial surfaces. The lungs are responsible for most morbidity, though other organs are frequently affected. Sleep abnormalities have long been recognized in CF. Abnormal ventilation and oxygenation, sinus disease, deconditioning due to muscle weakness and recurrent infections, and inflammation have been thought to play a role in sleep disorders in CF. However, there is evidence that CFTR gene dysregulation can affect circadian rhythms in CF. Early recognition and treatment of circadian rhythms may improve outcomes in CF.

Keywords: CFTR dysregulation; Circadian rhythm; Cystic fibrosis; Sleep disorders; Sleep quality.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
A 24-h schematic sleep schedules for advanced sleep phase, delayed sleep phase, non-24-h sleep–wake rhythm, and irregular sleep–wake rhythm disorders compared to the normal sleep phase. The black-filled bars represent the sleep period. Data from these sources [4, 11, 12]
See this image and copyright information in PMC

References

    1. Baron KG, Reid KJ. Circadian misalignment and health. Int Rev Psychiatry. 2014;26(2):139–154. doi: 10.3109/09540261.2014.911149. - DOI - PMC - PubMed
    1. Kondratova AA, Kondratov RV. The circadian clock and pathology of the ageing brain. Nat Rev Neurosci. 2012;13(5):325–335. doi: 10.1038/nrn3208. - DOI - PMC - PubMed
    1. Reddy S, Reddy V, Sharma S. Physiology, circadian rhythm. In: StatPearls. Treasure Island: StatPearls Publishing; 2021 [Online]. http://www.ncbi.nlm.nih.gov/books/NBK519507/. Accessed 2 Dec 2021.
    1. Shakkottai A, O’Brien LM, Nasr SZ, Chervin RD. Sleep disturbances and their impact in pediatric cystic fibrosis. Sleep Med Rev. 2018;42:100–110. doi: 10.1016/j.smrv.2018.07.002. - DOI - PMC - PubMed
    1. Huang C-Y, et al. The association between zolpidem and infection in patients with sleep disturbance. J Psychiatr Res. 2014;54:116–120. doi: 10.1016/j.jpsychires.2014.03.017. - DOI - PubMed

LinkOut - more resources