Gut barrier disruption and chronic disease

Jan Martel¹, Shih-Hsin Chang², Yun-Fei Ko³, Tsong-Long Hwang⁴, John D Young⁵, David M Ojcius⁶

Affiliations

¹ Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
² Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan.
³ Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Chang Gung Biotechnology Corporation, Taipei, Taiwan; Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan.
⁴ Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁵ Chang Gung Biotechnology Corporation, Taipei, Taiwan. Electronic address: jdyoung@mail.cgu.edu.tw.
⁶ Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Biomedical Sciences, Arthur Dugoni School of Dentistry, University of the Pacific, San Francisco, CA, USA. Electronic address: dojcius@pacific.edu.

PMID: 35151560
DOI: 10.1016/j.tem.2022.01.002

Review

Gut barrier disruption and chronic disease

Jan Martel et al. Trends Endocrinol Metab. 2022 Apr.

. 2022 Apr;33(4):247-265.

doi: 10.1016/j.tem.2022.01.002. Epub 2022 Feb 9.

Authors

Jan Martel¹, Shih-Hsin Chang², Yun-Fei Ko³, Tsong-Long Hwang⁴, John D Young⁵, David M Ojcius⁶

Affiliations

¹ Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
² Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan.
³ Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Chang Gung Biotechnology Corporation, Taipei, Taiwan; Biochemical Engineering Research Center, Ming Chi University of Technology, New Taipei City, Taiwan.
⁴ Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
⁵ Chang Gung Biotechnology Corporation, Taipei, Taiwan. Electronic address: jdyoung@mail.cgu.edu.tw.
⁶ Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Biomedical Sciences, Arthur Dugoni School of Dentistry, University of the Pacific, San Francisco, CA, USA. Electronic address: dojcius@pacific.edu.

PMID: 35151560
DOI: 10.1016/j.tem.2022.01.002

Abstract

The intestinal barrier protects the host against gut microbes, food antigens, and toxins present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic and extrinsic factors, including genetic predisposition, the Western diet, antibiotics, alcohol, circadian rhythm disruption, psychological stress, and aging. Chronic disruption of the gut barrier can lead to translocation of microbial components into the body, producing systemic, low-grade inflammation. While the association between gut barrier integrity and inflammation in intestinal diseases is well established, we review here recent studies indicating that the gut barrier and microbiota dysbiosis may contribute to the development of metabolic, autoimmune, and aging-related disorders. Emerging interventions to improve gut barrier integrity and microbiota composition are also described.

Keywords: dietary fiber; gut barrier integrity; gut microbiota; leaky gut; mucus; phytochemicals.

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Conflict of interest statement

Declaration of interests Y-F.K. is President of Chang Gung Biotechnology. J.D.Y. is Chairman of the Board of Chang Gung Biotechnology. J.M., Y-F.K., T-L.H., J.D.Y., and D.M.O. are named on patents held by Chang Gung University and/or Chang Gung Biotechnology related to the preparation and use of prebiotics, probiotics, and bioactive compounds.

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Gut barrier disruption and chronic disease

Affiliations

Gut barrier disruption and chronic disease

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources