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Review
. 2022 Apr 1;27(2):148-153.
doi: 10.1097/MOT.0000000000000967.

Autologous gastrointestinal reconstruction surgery for short bowel syndrome: the cornerstone for intestinal rehabilitation

Gabriel E Gondolesi  1   2 , Mariana Ortega  2 , Maria I Martinez  2 , Carolina Rumbo  2 , Héctor Solar  2
Affiliations
Review

Autologous gastrointestinal reconstruction surgery for short bowel syndrome: the cornerstone for intestinal rehabilitation

Gabriel E Gondolesi et al. Curr Opin Organ Transplant. .

Abstract

Purpose of review: Intestinal failure (IF) evolved from being the last recognized organ failure, to become one of the most progressive fields in terms of therapeutic alternatives and results. Short bowel syndrome (SBS) is the main cause of IF in adults and children. The use of surgery allowed patients with unfavorable anatomy type and length to be wean off parenteral nutrition. We aim to evaluate its current impact on intestinal rehabilitation.

Recent findings: Autologous gastro-intestinal reconstructive surgery (AGIRS), including bowel lengthening contributes by converting patient's anatomy to a more favorable one, improving quality of life, and modifying the natural history of the disease, allowing to recover intestinal autonomy in approximately 70% of the adults and 50% of the children's with SBS-IF. The current use of postsurgical medical rehabilitation strategies including the use of enterohormones complement the path to sufficiency, increasing the chances of success in both age group of patients.

Summary: The development of AGIRS has changed the outcome of SBS-IF patients, becoming the main surgical procedure prescribed in multidisciplinary units, allowing to enhance the number of patients achieving intestinal autonomy throughout rehabilitation, leaving transplantation as the last surgical alternative.

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References

    1. Gondolesi G, Doeyo M, Echevarria C, et al. Results of surgical and medical rehabilitation for adult patients with Type III intestinal failure in a comprehensive unit today: building a new model to predict parenteral nutrition independency. JPEN J Parenter Enteral Nutr 2020; 44:703–713.
    1. Lauro A, Coletta R, Morabito A. Restoring gut physiology in short bowel patients: from bench to clinical application of autologous intestinal reconstructive procedures. Expert Rev Gastroenterol Hepatol 2019; 13:785–796.
    1. Morabito A, Ugolini S, Cianci M, Coletta R. Current surgical concepts and indications in the management of the short bowel state: a call for the use of multidisciplinary intestinal rehabilitation programs. Children 2021; 8:654.
    1. Ramos-Gonzalez G, Kim HB. Autologous intestinal reconstruction surgery. Semin Pediatr Surg 2018; 27:261–266.
    1. Abu-Elmagd KM, Armanyous SR, Fujiki M, et al. Management of five hundred patients with gut failure at a single center: surgical innovation versus transplantation with a novel predictive model. Ann Surg 2019; 270:656–674.