Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jan 28:17:e02.
doi: 10.15420/icr.2021.14. eCollection 2022 Jan.

Best Practice in Intravascular Lithotripsy

Affiliations
Review

Best Practice in Intravascular Lithotripsy

Benjamin Honton et al. Interv Cardiol. .

Abstract

Intravascular lithotripsy (IVL) is a novel approach to lesion preparation of severely calcified plaques in coronary and peripheral vessels. Lithotripsy is delivered by vaporising fluid to create an expanding bubble that generates sonic pressure waves that interact with arterial calcification. Available data indicate that IVL leads to increased vessel compliance before stent implantation with high efficacy and an excellent safety profile. Since it gained the CE mark in 2017, and with improved operator experience, the use of IVL has expanded into more complex clinical situations. This review focuses on the best practice for IVL use in the cath lab, based on 3 years of experience with the technology and the latest scientific data from the Disrupt CAD clinical trials.

Keywords: Disrupt CAD; Intravascular lithotripsy; best practice; coronary calcified lesion; plaque modification.

PubMed Disclaimer

Conflict of interest statement

Disclosure: BH receives speaker fees from Shockwave. JM has no conflicts of interest to declare. Support: The publication of this article was supported by Shockwave Medical Inc.

Figures

Figure 1:
Figure 1:. Intravascular Lithotripsy Shockwave System
Figure 2:
Figure 2:. Decision Algorithm for Treatment of Calcified Coronary Vessels
Figure 3:
Figure 3:. Typical Multiplane and Longitudinal Optical Coherence Tomography Fractures with Immediate Lumen Gain Increased After Stent Delivery
Figure 4:
Figure 4:. Calcic Microfractures Induced by Intravascular Lithotripsy in Micro CT and Histology
Figure 5:
Figure 5:. Intravascular Lithotripsy in Severe Calcified Unprotected Left Main Lesion

References

    1. Lee MS, Shah N. The impact and pathophysiologic consequences of coronary artery calcium deposition in percutaneous coronary interventions. J Invasive Cardiol. 2016;28:160–7. - PubMed
    1. Wiemer M, Butz T, Schmidt W et al. Scanning electron microscopic analysis of different drug eluting stents after failed implantation: from nearly undamaged to major damaged polymers. Catheter Cardiovasc Interv. 2010;75:905–11. doi: 10.1002/ccd.22347. - DOI - PubMed
    1. Tzafriri AR, Garcia-Polite F, Zani B et al. Calcified plaque modification alters local drug delivery in the treatment of peripheral atherosclerosis. J Control Release. 2017;264:203–10. doi: 10.1016/j.jconrel.2017.08.037. - DOI - PMC - PubMed
    1. Mori S, Yasuda S, Kataoka Y et al. Significant association of coronary artery calcification in stent delivery route with restenosis after sirolimus-eluting stent implantation. Circ J. 2009;73:1856–63. doi: 10.1253/circj.CJ-09-0080. - DOI - PubMed
    1. Kobayashi Y, Okura H, Kume T et al. Impact of target lesion coronary calcification on stent expansion. Circ J. 2014;78:2209–14. doi: 10.1253/circj.CJ-14-0108. - DOI - PubMed