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Review
. 2022 Feb 4:2022:6025900.
doi: 10.1155/2022/6025900. eCollection 2022.

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Mohammed M Alshehri  1 , Cristina Quispe  2 , Jesús Herrera-Bravo  3   4 , Javad Sharifi-Rad  5 , Sena Tutuncu  6 , Elif Feyza Aydar  6 , Cansu Topkaya  7 , Zehra Mertdinc  6 , Beraat Ozcelik  6   8 , Mahima Aital  9 , N V Anil Kumar  9 , Natallia Lapava  10 , Jovana Rajkovic  11 , Andrea Ertani  12 , Silvana Nicola  12 , Prabhakar Semwal  13   14 , Sakshi Painuli  13   15 , Carlos González-Contreras  16 , Miquel Martorell  16   17 , Monica Butnariu  18 , Iulia Cristina Bagiu  19   20 , Radu Vasile Bagiu  19   21 , Mrunal D Barbhai  22 , Manoj Kumar  22 , Sevgi Durna Daştan  23   24 , Daniela Calina  25 , William C Cho  26
Affiliations
Review

A Review of Recent Studies on the Antioxidant and Anti-Infectious Properties of Senna Plants

Mohammed M Alshehri et al. Oxid Med Cell Longev. .

Abstract

The use of phytochemicals is gaining interest for the treatment of metabolic syndromes over the synthetic formulation of drugs. Senna is evolving as one of the important plants which have been vastly studied for its beneficial effects. Various parts of Senna species including the root, stem, leaves, and flower are found rich in numerous phytochemicals. In vitro, in vivo, and clinical experiments established that extracts from Senna plants have diverse beneficial effects by acting as a strong antioxidant and antimicrobial agent. In this review, Senna genus is comprehensively discussed in terms of its botanical characteristics, traditional use, geographic presence, and phytochemical profile. The bioactive compound richness contributes to the biological activity of Senna plant extracts. The review emphasizes on the in vivo and in vitro antioxidant and anti-infectious properties of the Senna plant. Preclinical studies confirmed the beneficial effects of the Senna plant extracts and its bioactive components in regard to the health-promoting activities. The safety, side effects, and therapeutic limitations of the Senna plant are also discussed in this review. Additional research is necessary to utilize the phenolic compounds towards its use as an alternative to pharmacological treatments and even as an ingredient in functional foods.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Geographical distribution of Senna species. All the regions where Senna plants are most common are highlighted in red
Figure 2
Figure 2
Chemical structures of mostly identified phytochemical compounds in Senna plants.
Figure 3
Figure 3
Antioxidant activity of bioactive compounds of Senna plants. The antioxidant bioactive molecules contained in Senna species neutralize free radicals by releasing electrons.
Figure 4
Figure 4
Anti-infectious properties of the most representative bioactive compounds of Senna plants. Botanical molecules such us alkaloids, sennoides, anthraquinones, phenolics, terpenoids, alkaloids, and triterpenoids have anti-infectious activity against bacteria, fungus, protozoa, and viruses (HIV, Coxsackie, and Herpes simplex).
Figure 5
Figure 5
Summarized scheme with side effects and clinical therapeutic limitations of Senna plant.
See this image and copyright information in PMC

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