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. 2021 Dec 13;10(2):499-506.
doi: 10.1002/fsn3.2683. eCollection 2022 Feb.

Exploring the potential of curry leaves on mercury-induced hepatorenal toxicity in an animal model

Muhammad Ijaz  1 , Asma Arshad  2 , Muhammad Ahmad Awan  3 , Muhammad Rizwan Tariq  4 , Shinawar Waseem Ali  4 , Sajid Ali  4 , Muhammad Shafiq  4 , Saeed Ahmed  5 , Muhammad Naveed Sheas  6 , Madiha Iftikhar  6 , Sheraz Ahmed  7 , Muhammad Adnan Nasir  8 , Ghazala Kausar  9 , Ammad Ul Islam Javed  3 , Waseem Safdar  5
Affiliations

Exploring the potential of curry leaves on mercury-induced hepatorenal toxicity in an animal model

Muhammad Ijaz et al. Food Sci Nutr. .

Abstract

Herbal drugs play an imperative role in healthcare programs in developing countries. Curry leaves have wide medicinal importance and are used to treat various diseases traditionally. The current study was carried out to estimate the extent of mercury toxicity and the potential effect of curry leaves against defined toxicity. The study group comprised 24 rats weighing between 130 and150 g. Group 1 was kept normal, and group 2 was exposed to mercury at 0.4 mg/kg of body weight in the form of mercuric chloride (HgCl2). The group 3 animals were treated with curry leaves with a dosage of 300 mg/kg of body weight. Group 4 was treated with curry leaves along with mercury with a dosage of 300 and 0.4 mg/kg consecutively. After 28 days, the rats were killed. Blood sample of all groups were evaluated separately to determine the results of different parameters. The results show that ALP, AST, ALT, urea, bilirubin, and creatinine increased with mercury application and decreased with curry leaf exposure. SOD, CAT, GPx, and GR of the liver as well as the kidney depleted on mercury exposure whereas they increased with curry leaf application. HDL increased with curry leaf application and decreased with mercury treatment, while LDL, triglyceride, and cholesterol decreased with curry leaves and increased with mercury exposure. Organ index in mercury along with curry leaf application got close to normal.

Keywords: curry; kidney; lipid profile; liver; toxicity.

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Conflict of interest statement

The authors do not have any conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic representation of methodology used to explore the effect of curry leaves on mercury‐induced hepatorenal toxicity. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAT, catalase; Chol, cholesterol; GPx, glutathione peroxidase; GR, glutathione reductase; HDL, high‐density lipoprotein; HgCl2, mercuric chloride; KI, kidney index; LDL, low‐density lipoprotein; LI, liver index; PI, pancreas index; SOD, superoxide dismutase; TG, triglycerides
FIGURE 2
FIGURE 2
The overall mean effect of curry leaves on mercury‐induced hepatorenal toxicity. Results with different superscripts were significantly different from each other (p > .05). G0: control fed normal diet; G1: introduced 0.4 mg/kg body weight HgCl2; G2: introduced extract of 300 mg/kg body weight curry leaves; G3: mixture of HgCl2 (0.4 mg/kg) + extract of curry leaves (300 mg/kg) + 1% sodium carboxymethyl cellulose
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