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Case Reports
. 2022 Jan 6;14(1):e20997.
doi: 10.7759/cureus.20997. eCollection 2022 Jan.

An Unlikely Trio: Profound Anemia, Elevated Lactate, and Riociguat

Mary Jo S Farmer  1 , Harrison W Farber  2
Affiliations
Case Reports

An Unlikely Trio: Profound Anemia, Elevated Lactate, and Riociguat

Mary Jo S Farmer et al. Cureus. .

Abstract

Riociguat (Adempas) is a stimulator of soluble guanylate cyclase approved to treat adult pulmonary arterial hypertension (PAH), World Health Organization (WHO) group 1 pulmonary hypertension (PH), and inoperable or persistent chronic thromboembolic pulmonary hypertension (CTEPH), WHO group 4 PH. Riociguat has been studied predominantly in WHO functional class II and III patients. In the pivotal Pulmonary Arterial Hypertension Soluble Guanylate Stimulator Trial 1 (PATENT-1) clinical trial, anemia was reported in 8% of patients; however, this anemia was typically very mild. We present a unique case of profound anemia and elevated lactate occurring in a patient taking riociguat for treatment of PAH.

Keywords: adempas; anemia; chronic thromboembolic pulmonary hypertension; cteph; lactate; pah; pulmonary arterial hypertension; pulmonary hypertension; riociguat.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Hemoglobin and Hematocrit
Hgb: hemoglobin; Hct: hematocrit. Day 0: baseline hemoglobin and hematocrit values.
Figure 2
Figure 2. Relationship Between Oxygen Delivery (DO2) and Oxygen Consumption (VO2)
See this image and copyright information in PMC

References

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