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Review
. 2022 Apr;37(4):889-900.
doi: 10.1007/s11011-022-00931-8. Epub 2022 Feb 14.

A focus on natural products for preventing and cure of mitochondrial dysfunction in Parkinson's disease

Abbas Mohammadipour  1
Affiliations
Review

A focus on natural products for preventing and cure of mitochondrial dysfunction in Parkinson's disease

Abbas Mohammadipour. Metab Brain Dis. 2022 Apr.

Abstract

Mitochondria are considered the only source of energy production within cells. This organelle is vital for neural function and survival by producing energy (adenosine triphosphate (ATP)) and regulating intracellular calcium. Mitochondrial dysfunction, which significantly contributes to both idiopathic and familial types of Parkinson's disease (PD), depletes cellular energy, disrupts homeostasis, and induces oxidative stress, leading to cell death. In recent years several natural products have been discovered to be protective against mitochondrial dysfunction. This review discusses the role of mitochondria in the progression of PD to define the path for using natural products to prevent and/or cure PD.

Keywords: Mitochondrial dysfunction; Molecular mechanisms; Natural products; Neuroprotection; Parkinson’s disease.

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References

    1. Akbay P, Basaran AA, Undeger U, Basaran N (2003) In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L. Phytother Res. 17(1):34–37. https://doi.org/10.1002/ptr.1068 - DOI - PubMed
    1. Angelopoulou E, Pyrgelis ES, Piperi C (2020) Neuroprotective potential of chrysin in Parkinson’s disease: Molecular mechanisms and clinical implications. Neurochemistry international. 132:104612. https://doi.org/10.1016/j.neuint.2019.104612 - DOI - PubMed
    1. Anis E, Zafeer MF, Firdaus F, Islam SN, Anees Khan A, Ali A, Hossain MM (2020) Ferulic acid reinstates mitochondrial dynamics through PGC1α expression modulation in 6-hydroxydopamine lesioned rats. Phytotherapy research. 34(1):214–226. https://doi.org/10.1002/ptr.6523 - DOI - PubMed
    1. Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA (2009) Protective effect of quercetin in primary neurons against Abeta (1–42): relevance to Alzheimer’s disease. The Journal of nutritional biochemistry. 20:269–275. https://doi.org/10.1016/j.jnutbio.2008.03.002 - DOI - PubMed
    1. Antonsson B (2004) Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways. Mol Cell Biochem. 256-257(1-2):141–155. https://doi.org/10.1023/B:MCBI.0000009865.70898.36 - DOI - PubMed

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