RHCE null allele causing D-- phenotype in a Latin-American blood donor

Affiliations

¹ Department of Immunohematology, Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, Brazil.
² Department of Banco de Sangre, Hospital Nacional Daniel A. Carrión, Lima, Peru.
³ Department of Imunohematologia, BIORAD, Lagoa Santa, Minas Gerais, Brazil.
⁴ Serviço de Hematologia, Hemoterapia e Terapia Celular do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
⁵ Department of Hematology, Churchill Hospital, NHS BT, Oxford University, Oxford, UK.
⁶ Institute of Tropical Medicine, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Case Reports

Marcia Regina Dezan et al. Transfusion. 2022 Mar.

. 2022 Mar;62(3):E21-E23.

doi: 10.1111/trf.16824. Epub 2022 Feb 13.

¹ Department of Immunohematology, Fundação Pró-Sangue Hemocentro de São Paulo, São Paulo, Brazil.
² Department of Banco de Sangre, Hospital Nacional Daniel A. Carrión, Lima, Peru.
³ Department of Imunohematologia, BIORAD, Lagoa Santa, Minas Gerais, Brazil.
⁴ Serviço de Hematologia, Hemoterapia e Terapia Celular do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
⁵ Department of Hematology, Churchill Hospital, NHS BT, Oxford University, Oxford, UK.
⁶ Institute of Tropical Medicine, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

No abstract available

Keywords: Rh17; RhD--Rh blood group system.

References

1. Daniels G. Human blood groups. 3rd edition. UK: John Wiley & Sons; 2013.
1. Chen Q, Xiao J, Zhang M, Huang C, Li M, Flegel WA, et al. A null allele caused by a four-base-pair duplication within the RHCE gene encoding a D- - phenotype. Transfusion. 2021;61:E23-e5.
1. Sippert E, Volkova E, Denomme GA, Liu M, Liu Z, Rios M. New RHCE*ce variant allele in African descent holds 105C>T (silent) in cis to 48C in Exon 1 and 733G in Exon 5. Transfusion. 2019;59:3039-40.
1. Paccapelo C, Peyrard T, Vrignaud C, Beigenger A, Truglio F, Spaltro G, Revelli N, Villa MA, Prati D: A Novel Mutation in the RHCE Gene Resulting in the Exceptional D--Phenotype. 2018 Annual Meeting: AABB, 2018.