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Editorial
. 2022 Feb 15;11(4):e024740.
doi: 10.1161/JAHA.121.024740. Epub 2022 Feb 12.

Mechanosensitive Angiotensin II Receptor Signaling in Pressure-Induced Vasoconstriction

Yen-Lin Chen  1   2 , Swapnil K Sonkusare  1   2
Affiliations
Editorial

Mechanosensitive Angiotensin II Receptor Signaling in Pressure-Induced Vasoconstriction

Yen-Lin Chen et al. J Am Heart Assoc. .
No abstract available

Keywords: Editorials; angiotensin II type 1a receptor; biased ligands; myogenic vasoconstriction/arterial smooth muscle.

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Figures

Figure 1
Figure 1. Schematic diagram showing AT1aR‐dependent signaling activated by intraluminal pressure.
Intraluminal pressure induces vascular smooth muscle cells (SMC) contraction via AT1aR activation and Gq/11 signaling. Activation of AT1aRs elicits TRPC6 channel−TRPM4 channel signaling and membrane depolarization. The figure also shows potential signaling linkages of AT1aRs with TRPV4 and Piezo1 channels on the SMC membrane. AT1aR indicates angiotensin II 1a receptor subtype; BK channel, Ca2+‐activated large‐conductance K+ channel; G12/13, G proteins 12/13 subunits; Gq/11, G proteins q/11 subunits; TRPC6, transient receptor potential canonical 6; TRPM4, transient receptor potential melastatin 4; and TRPV4, transient receptor potential vanilloid 4.
See this image and copyright information in PMC

Comment on

References

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