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. 2022 Feb 15;11(4):e021583.
doi: 10.1161/JAHA.121.021583. Epub 2022 Feb 12.

Heart Failure Risk Associated With Severity of Modifiable Heart Failure Risk Factors: The ARIC Study

Carine E Hamo  1 , Lucia Kwak  2 , Dan Wang  2 , Roberta Florido  1 , Justin B Echouffo-Tcheugui  2   3 , Roger S Blumenthal  1 , Laura Loehr  4 , Kunihiro Matsushita  2 , Vijay Nambi  5   6 , Christie M Ballantyne  6 , Elizabeth Selvin  2 , Aaron R Folsom  7 , Gerardo Heiss  4 , Josef Coresh  2 , Chiadi E Ndumele  1   2
Affiliations

Heart Failure Risk Associated With Severity of Modifiable Heart Failure Risk Factors: The ARIC Study

Carine E Hamo et al. J Am Heart Assoc. .
No abstract available

Keywords: diabetes; heart failure; hypertension; obesity; risk factors.

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Figures

Figure 1
Figure 1. Absolute risks of heart failure associated with the levels of control and number of modifiable risk factors.
A, Kaplan–Meier curve for grouped categorization of modifiable risk factors. Probability of remaining free of heart failure based on categorizations of control of the 3 major modifiable risk factors (hypertension, diabetes, and obesity): No risk factors defined as no hypertension, no diabetes, and body mass index (BMI) <30 kg/m2; controlled risk factors defined as hypertension with systolic blood pressure <130 mm Hg and/or diabetes with hemoglobin A1c<7%, and BMI <30 kg/m2; mild‐to‐moderately uncontrolled risk factors (any of the following): hypertension with systolic blood pressure 130 to <160 mm Hg; diabetes with hemoglobin A1c 7% to 8%; BMI 30 to 35 kg/m2; severely uncontrolled risk factors (any of the following): hypertension with systolic blood pressure ≥160 mm Hg; diabetes with hemoglobin A1c ≥8%; and BMI ≥35 kg/m2. Those with BMI <18.5 kg/m2 (n=122) were excluded from this analysis. Each subgroup name is followed by prevalence in the study population in parentheses. B, Adjusted heart failure incidence rates for grouped categorization of modifiable risk factors. Adjusted incidence rates presented per 1000 person‐years for different categorizations of control of 3 major modifiable risk factors (hypertension, diabetes, and obesity). Incidence rates calculated at mean levels of sex, race, occupation, education, smoking status, alcohol intake, high‐density lipoprotein cholesterol, triglycerides, low‐density lipoprotein cholesterol, and estimated glomerular filtration rate in the study population.
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References

    1. Uijl A, Koudstaal S, Vaartjes I, Boer JM, Verschuren WMM, Van der Schouw YT, Asselbergs FW, Hoes AW, Slujis I. Risk for heart failure: the opportunity for prevention with the American Heart Association's Life's Simple 7. JACC Heart Fail. 2019;7:637–647. doi: 10.1016/j.jchf.2019.03.009 - DOI - PubMed
    1. Folsom AR, Shah AM, Lutsey PL, Roetker NS, Alonso A, Avery CL, Miedema MD, Konety S, Chang PP, Solomon SD. American Heart Association's life's simple 7: avoiding heart failure and preserving cardiac structure and function. Am J Med. 2015;128:970–6.e2. doi: 10.1016/j.amjmed.2015.03.027 - DOI - PMC - PubMed
    1. Kenchaiah S, Evans JC, Levy D, Wilson PWF, Benjamin EJ, Larson MG, Kannel WB, Vasan RS. Obesity and the risk of heart failure. N Engl J Med. 2002;347:305–313. doi: 10.1056/NEJMoa020245 - DOI - PubMed
    1. Rodriguez CJ, Swett K, Agarwal SK, Folsom AR, Fox ER, Loehr LR, Ni H, Rosamond WD, Chang PP. Systolic blood pressure levels among adults with hypertension and incident cardiovascular events: the atherosclerosis risk in communities study. JAMA Intern Med. 2014;174:1252–1261. doi: 10.1001/jamainternmed.2014.2482 - DOI - PMC - PubMed
    1. Matsushita K, Blecker S, Pazin‐Filho A, Bertoni A, Chang PP, Coresh J, Selvin E. The association of hemoglobin A1c with incident heart failure among people without diabetes: the atherosclerosis risk in communities study. Diabetes. 2010;59:2020–2026. doi: 10.2337/db10-0165 - DOI - PMC - PubMed

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