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Review
. 2022 Feb 6;14(3):817.
doi: 10.3390/cancers14030817.

Use of Omics Technologies for the Detection of Colorectal Cancer Biomarkers

Marina Alorda-Clara  1   2 , Margalida Torrens-Mas  1   2   3 , Pere Miquel Morla-Barcelo  1 , Toni Martinez-Bernabe  1   2 , Jorge Sastre-Serra  1   2   4 , Pilar Roca  1   2   4 , Daniel Gabriel Pons  1   2 , Jordi Oliver  1   2   4 , Jose Reyes  1   2   5
Affiliations
Review

Use of Omics Technologies for the Detection of Colorectal Cancer Biomarkers

Marina Alorda-Clara et al. Cancers (Basel). .

Abstract

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers with high mortality rates, especially when detected at later stages. Early detection of CRC can substantially raise the 5-year survival rate of patients, and different efforts are being put into developing enhanced CRC screening programs. Currently, the faecal immunochemical test with a follow-up colonoscopy is being implemented for CRC screening. However, there is still a medical need to describe biomarkers that help with CRC detection and monitor CRC patients. The use of omics techniques holds promise to detect new biomarkers for CRC. In this review, we discuss the use of omics in different types of samples, including breath, urine, stool, blood, bowel lavage fluid, or tumour tissue, and highlight some of the biomarkers that have been recently described with omics data. Finally, we also review the use of extracellular vesicles as an improved and promising instrument for biomarker detection.

Keywords: blood; bowel lavage fluid; breath; colorectal cancer; extracellular vesicles; omics; stool; tumour tissue; urine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Main types of samples and the omics applied to them.
See this image and copyright information in PMC

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