Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 26;11(3):422.
doi: 10.3390/cells11030422.

Cardiovascular Biomarker Profiles in Obesity and Relation to Normalization of Subclinical Cardiac Dysfunction after Bariatric Surgery

Sanne M Snelder  1 , Nadine Pouw  2 , Yaar Aga  1 , Manuel Castro Cabezas  3 , L Ulas Biter  4 , Felix Zijlstra  5 , Isabella Kardys  5 , Bas M van Dalen  1   5
Affiliations

Cardiovascular Biomarker Profiles in Obesity and Relation to Normalization of Subclinical Cardiac Dysfunction after Bariatric Surgery

Sanne M Snelder et al. Cells. .

Abstract

Aims: We aimed to gain insight into the underlying pathophysiology of cardiac dysfunction in obesity patients and the improvement of cardiac function after weight loss.

Methods: This is a longitudinal study in which 92 cardiovascular biomarkers were measured by multiplex immunoassays in obesity patients without known cardiovascular disease, before and one year after bariatric surgery.

Results: Out of 100 eligible patients, 72 patients completed the follow-up. A total of 72 (78%) biomarkers changed significantly. The biomarkers with the highest relative changes represented processes linked mainly to insulin resistance and inflammation. In the patients with persistent subclinical cardiac dysfunction, the baseline values of 10 biomarkers were different from values in patients with normalization of cardiac function. Most of these biomarkers were linked to inflammation or atherosclerosis. Finally, a model was developed to investigate the relationship between changes in the biomarkers and persistent subclinical cardiac dysfunction. Seven biomarkers were retained in this model, mainly linked to inflammation, atherosclerosis, and hypercoagulability.

Conclusion: The majority (78%) of cardiovascular biomarkers changed, pointing mainly to modulation of insulin resistance and inflammation. The baseline levels of 10 biomarkers, as well as pre- to post-bariatric surgery changes in seven biomarkers, were related to persistent subclinical cardiac dysfunction after bariatric surgery.

Keywords: bariatric surgery; biomarkers; cardiac dysfunction; obesity/obese.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of follow-up. DM = diabetes mellitus.
Figure 2
Figure 2
Graphical representation of the relative changes in all 92 biomarkers, pre- and post-bariatric surgery. * significant after Benjamini–Hochberg correction.
Figure 3
Figure 3
ROC curve for the elastic net model. Biomarkers included are CPB1, CASP3, SELP, GP6, PDGF-subunit A, TLT2, and vWF. AUC 0.91 (95% CI: 0.82–0.99, p < 0.001).
See this image and copyright information in PMC

References

    1. Di Angelantonio E., Bhupathiraju S.N., Wormser D., Gao P., Kaptoge S., Berrington de Gonzalez A., Cairns B.J., Huxley R., Jackson C.L., Joshy S., et al. Body-mass index and all-cause mortality: Individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet. 2016;388:776–786. doi: 10.1016/S0140-6736(16)30175-1. - DOI - PMC - PubMed
    1. Ward Z.J., Bleich S.N., Cradock A.L., Barrett J.L., Giles C.M., Flax C., Long M.W., Gortmaker S.L. Projected U.S. State-Level Prevalence of Adult Obesity and Severe Obesity. N. Engl. J. Med. 2019;381:2440–2450. doi: 10.1056/NEJMsa1909301. - DOI - PubMed
    1. Kenchaiah S., Evans J.C., Levy D., Wilson P.W., Benjamin E.J., Larson M.G., Kannel W.B., Vasan R.S. Obesity and the risk of heart failure. N. Engl. J. Med. 2002;347:305–313. doi: 10.1056/NEJMoa020245. - DOI - PubMed
    1. Snelder S.M., de Groot-de Laat L.E., Biter L.U., Castro Cabezas M., Pouw N., Birnie E., Boxma-de Klerk B.M., Klaassen R.A., Zijlstra F., van Dalen B.M. Subclinical cardiac dysfunction in obesity patients is linked to autonomic dysfunction: Findings from the CARDIOBESE study. ESC Heart Fail. 2020;7:3726–3737. doi: 10.1002/ehf2.12942. - DOI - PMC - PubMed
    1. DeMaria E.J. Bariatric surgery for morbid obesity. N. Engl. J. Med. 2007;356:2176–2183. doi: 10.1056/NEJMct067019. - DOI - PubMed

Publication types