Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

doi:10.3390/foods11030336

Review

. 2022 Jan 25;11(3):336.

doi: 10.3390/foods11030336.

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Luís R Silva^{1

2}, Telma A Jacinto¹, Paula Coutinho^{1

2}

Affiliations

¹ CPIRN-UDI/IPG-Centro de Potencial e Inovação em Recursos Naturais, Unidade de Investigação para o Desenvolvimento do Interior do Instituto Politécnico da Guarda, 6300-559 Guarda, Portugal.
² CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal.

PMID: 35159487
PMCID: PMC8915173
DOI: 10.3390/foods11030336

Review

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Luís R Silva et al. Foods. 2022.

. 2022 Jan 25;11(3):336.

doi: 10.3390/foods11030336.

Authors

Luís R Silva^{1

2}, Telma A Jacinto¹, Paula Coutinho^{1

2}

Affiliations

¹ CPIRN-UDI/IPG-Centro de Potencial e Inovação em Recursos Naturais, Unidade de Investigação para o Desenvolvimento do Interior do Instituto Politécnico da Guarda, 6300-559 Guarda, Portugal.
² CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal.

PMID: 35159487
PMCID: PMC8915173
DOI: 10.3390/foods11030336

Abstract

Cardoon (Cynara cardunculus L.) is a Mediterranean plant and member of the Asteraceae family that includes three botanical taxa, the wild perennial cardoon (C. cardunculus L. var. sylvestris (Lamk) Fiori), globe artichoke (C. cardunculus L. var. scolymus L. Fiori), and domesticated cardoon (C. cardunculus L. var. altilis DC.). Cardoon has been widely used in the Mediterranean diet and folk medicine since ancient times. Today, cardoon is recognized as a plant with great industrial potential and is considered as a functional food, with important nutritional value, being an interesting source of bioactive compounds, such as phenolics, minerals, inulin, fiber, and sesquiterpene lactones. These bioactive compounds have been vastly described in the literature, exhibiting a wide range of beneficial effects, such as antimicrobial, anti-inflammatory, anticancer, antioxidant, lipid-lowering, cytotoxic, antidiabetic, antihemorrhoidal, cardiotonic, and choleretic activity. In this review, an overview of the cardoon nutritional and phytochemical composition, as well as its biological potential, is provided, highlighting the main therapeutic effects of the different parts of the cardoon plant on metabolic disorders, specifically associated with hepatoprotective, hypolipidemic, and antidiabetic activity.

Keywords: Cynara cardunculus L.; Mediterranean plant; biological activities; metabolic disorders; phytochemical composition.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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1. Gonçalves A.C., Nunes A.R., Falcão A., Alves G., Silva L.R. Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review. Pharmaceuticals. 2021;14:690. doi: 10.3390/ph14070690. - DOI - PMC - PubMed

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[1] Vinagre C., Vinagre S., Carrilho E. The use of medicinal plants by the population from the Protected Landscape of “Serra de Montejunto”, Portugal. J. Ethnobiol. Ethnomed. 2019;15:30. doi: 10.1186/s13002-019-0309-0. - DOI - PMC - PubMed

[2] Vinagre C., Vinagre S., Carrilho E. The use of medicinal plants by the population from the Protected Landscape of “Serra de Montejunto”, Portugal. J. Ethnobiol. Ethnomed. 2019;15:30. doi: 10.1186/s13002-019-0309-0. - DOI - PMC - PubMed

[3] Alirezalu K., Pateiro M., Yaghoubi M., Alirezalu A., Peighambardoust S.H., Lorenzo J.M. Phytochemical constituents, advanced extraction technologies and techno-functional properties of selected Mediterranean plants for use in meat products. A comprehensive review. Trends Food Sci. Technol. 2020;100:292–306. doi: 10.1016/j.tifs.2020.04.010. - DOI

[4] Alirezalu K., Pateiro M., Yaghoubi M., Alirezalu A., Peighambardoust S.H., Lorenzo J.M. Phytochemical constituents, advanced extraction technologies and techno-functional properties of selected Mediterranean plants for use in meat products. A comprehensive review. Trends Food Sci. Technol. 2020;100:292–306. doi: 10.1016/j.tifs.2020.04.010. - DOI

[5] Ożarowski M., Karpiński T.M., Szulc M., Wielgus K., Kujawski R., Wolski H., Seremak-Mrozikiewicz A. Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials-Review of Perspectives for Novel Therapies. Pharmaceuticals. 2021;14:269. doi: 10.3390/ph14030269. - DOI - PMC - PubMed

[6] Ożarowski M., Karpiński T.M., Szulc M., Wielgus K., Kujawski R., Wolski H., Seremak-Mrozikiewicz A. Plant Phenolics and Extracts in Animal Models of Preeclampsia and Clinical Trials-Review of Perspectives for Novel Therapies. Pharmaceuticals. 2021;14:269. doi: 10.3390/ph14030269. - DOI - PMC - PubMed

[7] Newman D.J., Cragg G.M. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. J. Nat. Prod. 2020;83:770–803. doi: 10.1021/acs.jnatprod.9b01285. - DOI - PubMed

[8] Newman D.J., Cragg G.M. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. J. Nat. Prod. 2020;83:770–803. doi: 10.1021/acs.jnatprod.9b01285. - DOI - PubMed

[9] Gonçalves A.C., Nunes A.R., Falcão A., Alves G., Silva L.R. Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review. Pharmaceuticals. 2021;14:690. doi: 10.3390/ph14070690. - DOI - PMC - PubMed

[10] Gonçalves A.C., Nunes A.R., Falcão A., Alves G., Silva L.R. Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review. Pharmaceuticals. 2021;14:690. doi: 10.3390/ph14070690. - DOI - PMC - PubMed

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Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Affiliations

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Authors

Affiliations

Abstract

Conflict of interest statement

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References

Publication types

LinkOut - more resources

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