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Review
. 2022 Jan 31;11(3):770.
doi: 10.3390/jcm11030770.

Transplantation of Organs from Hepatitis C Virus-Positive Donors under Direct-Acting Antiviral Regimens

Muhammad Nauman Zahid  1
Affiliations
Review

Transplantation of Organs from Hepatitis C Virus-Positive Donors under Direct-Acting Antiviral Regimens

Muhammad Nauman Zahid. J Clin Med. .

Abstract

There is a discrepancy between the patients requiring organ transplants and the donors available to meet that demand. Many patients die every year while on the waiting list, and there is a need to bridge this gap. For many years, medical practitioners have been apprehensive of using donor organs from donors who have tested positive for the Hepatitis C virus (HCV), and with good reason. HCV has been proven to be among the leading causes of liver diseases requiring liver transplants. Over the years, studies have been carried out to find a treatment for Hepatitis C. The advent of direct-acting antivirals revolutionized the medical world. These medication regimens have been proven to treat Hepatitis C in transplant patients effectively. This systematic review will examine how DAA treatments affect transplants of different organs from HCV-positive donors to HCV-negative recipients.

Keywords: HCV-positive donors; Hepatitis C infection; Hepatitis C virus; direct-acting antiviral agents; liver transplantation; organ transplantation.

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Conflict of interest statement

The author declares that he has no competing interest.

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References

    1. World Health Organization Hepatitis C: Fact Sheet NO164. 2015. [(accessed on 27 July 2021)]. Available online: http://www.who.int/mediacentre/factsheets/fs164/en/
    1. American Transplant Foundation Facts and Myths about Transplant. [(accessed on 12 August 2021)]. Available online: https://www.americantransplantfoundation.org/about-transplant/facts-and-...
    1. Organ Donation and Transplantation NHS Blood and Transplant. [(accessed on 15 August 2021)]. Available online: https://www.nhsbt.nhs.uk/what-we-do/transplantation-services/organ-donat...
    1. Centres for Disease Control and Prevention Viral Hepatitis Surveillance Report—United States. [(accessed on 30 September 2021)];2019 Available online: https://www.cdc.gov/hepatitis/statistics/2019surveillance/index.htm.
    1. Zibbell J.E., Asher A.K., Patel R.C., Kupronis B., Iqbal K., Ward J.W., Holtzman D. Increases in acute Hepatitis C virus infection related to a growing opioid epidemic and associated injection drug use, United States, 2004 to 2014. [(accessed on 15 August 2021)];Am. J. Public. Health. 2018 108:175–181. doi: 10.2105/AJPH.2017.304132. Available online: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846578/pdf/AJPH.2017.30413.... - DOI - PMC - PubMed

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