Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jan 24;15(3):875.
doi: 10.3390/ma15030875.

State of the Art in Gold Nanoparticle Synthesisation via Pulsed Laser Ablation in Liquid and Its Characterisation for Molecular Imaging: A Review

Siti Zaleha Mat Isa  1 , Rafidah Zainon  1 , Mahbubunnabi Tamal  2
Affiliations
Review

State of the Art in Gold Nanoparticle Synthesisation via Pulsed Laser Ablation in Liquid and Its Characterisation for Molecular Imaging: A Review

Siti Zaleha Mat Isa et al. Materials (Basel). .

Abstract

With recent advances in nanotechnology, various nanomaterials have been used as drug carriers in molecular imaging for the treatment of cancer. The unique physiochemical properties and biocompatibility of gold nanoparticles have developed a breakthrough in molecular imaging, which allows exploration of gold nanoparticles in drug delivery for diagnostic purpose. The conventional gold nanoparticles synthetisation methods have limitations with chemical contaminations during the synthesisation process and the use of higher energy. Thus, various innovative approaches in gold nanoparticles synthetisation are under development. Recently, studies have been focused on the development of eco-friendly, non-toxic, cost-effective and simple gold nanoparticle synthesisation. The pulsed laser ablation in liquid (PLAL) technique is a versatile synthetic and convincing technique due to its high efficiency, eco-friendly and facile method to produce gold nanoparticle. Therefore, this study aimed to review the eco-friendly gold nanoparticle synthesisation method via the PLAL method and to characterise the gold nanoparticles properties for molecular imaging. This review paper provides new insight to understand the PLAL technique in producing gold nanoparticles and the PLAL parameters that affect gold nanoparticle properties to meet the desired needs in molecular imaging.

Keywords: characterisation; gold nanoparticle; molecular imaging; pulsed laser ablation in liquid; synthesisation.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1
Figure 1
Histogram of the size distribution on TEM images of the gold nanoparticles produced by (a) 1064 nm and (b) 532 nm in distilled water (retrieved with permission from reference [33]).
Figure 2
Figure 2
Average size of gold nanoparticles synthesised by 1064 nm wavelength laser ablation at energy of 45, 128, 213 and 307 mJ (retrieved with permission from reference [32]).
Figure 3
Figure 3
Absorption study from the ablation metal (Gold and Sn) immersed in pure water in time dependent over a day (retrieved with permission from reference [40]).
See this image and copyright information in PMC

References

    1. Sengani M., Grumezescu A.M., Rajeswari V.D. Recent trends and methodologies in gold nanoparticle synthesis—A prospective review on drug delivery aspect. OpenNano. 2017;2:37–46. doi: 10.1016/j.onano.2017.07.001. - DOI
    1. Herizchi R., Abbasi E., Milani M., Akbarzadeh A. Current methods for synthesis of gold nanoparticles. Artif. Cells Nanomed. Biotechnol. 2016;44:596–602. doi: 10.3109/21691401.2014.971807. - DOI - PubMed
    1. Mohazzab B.F., Jaleh B., Nasrollahzadeh M., Issaabadi Z., Varma R.S. Laser ablation-assisted synthesis of GO/TiO2/Au nanocomposite: Applications in K3[Fe(CN)6] and Nigrosin reduction. Mol. Catal. 2019;473:110401. doi: 10.1016/j.mcat.2019.110401. - DOI
    1. Nancy P., Nair A.K., Antoine R., Thomas S., Kalarikkal N. In situ decoration of gold nanoparticles on graphene oxide via nanosecond laser ablation for remarkable chemical sensing and catalysis. Nanomaterials. 2019;9:1201. doi: 10.3390/nano9091201. - DOI - PMC - PubMed
    1. Hernández-Maya M., Rivera-Quintero P., Ospina R., Quintero-Orozco J.H., García-Castro A.C. Ablation energy, water volume and ablation time: Gold nanoparticles obtained through by pulsed laser ablation in liquid. J. Phys. Conf. Ser. 2019;1386 doi: 10.1088/1742-6596/1386/1/012062. - DOI

LinkOut - more resources