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. 2022 Jan 24;19(3):1288.
doi: 10.3390/ijerph19031288.

Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review

Erica Morales-Rodriguez  1   2 , Txomin Pérez-Bilbao  2   3 , Alejandro F San Juan  2 , Jorge Lorenzo Calvo  1
Affiliations

Effects of Exercise Programs on Physical Factors and Safety in Adult Patients with Cancer and Haematopoietic Stem Cell Transplantation: A Systematic Review

Erica Morales-Rodriguez et al. Int J Environ Res Public Health. .

Abstract

This study looks at the effects of exercise programs on physical factors and safety in adult patients with cancer and hematopoietic stem cell transplantation (HSCT) or bone marrow transplantation (BMT). A systematic search was performed in the PubMed and Web of Science databases (from inception to 26 August 2021). A review was carried out following the Preferred Reporting Items for Systematic review and Meta-Analyses (PRISMA) checklist. The methodological quality of the included studies was assessed with the Physiotherapy Evidence Database (PEDro) scale, based, in turn, on the Delphi list. A total of 25 randomized controlled trials studies were included, comprising 1434 patients. The most significant result of this systematic review is that exercise program interventions are safe and produce positive changes in cardiorespiratory fitness, muscle strength, and the functional mobility-state in adult patients with cancer and HSCT or BMT. Only 3 patients from the 711 participants in the exercise interventions (i.e., 0.42%) reported adverse events related to exercise interventions. Moreover, exercise training programs may have a cardiological and muscular protective effect, as well as a healthy effect on the prevention and control of transplant complications, improving health outcomes.

Keywords: bone marrow transplant; cancer; exercise; fitness; hematopoietic stem cell transplantation.

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Conflict of interest statement

The authors declare no conflict of interest.

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Systematic review flow chart.
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References

    1. Battaglini C.L., Hackney A.C., Garcia R., Groff D., Evans E., Shea T. The Effects of an Exercise Program in Leukemia Patients. [(accessed on 24 February 2021)];Integr. Cancer Ther. 2009 8:130–138. doi: 10.1177/1534735409334266. Available online: http://journals.sagepub.com/doi/10.1177/1534735409334266. - DOI - DOI - PubMed
    1. Moya R., Espigado I., Parody R., Carmona M., Márquez F., De Blas J.M. Evaluation of Readmissions in Hematopoietic Stem Cell Transplant Recipients. Transplant. Proc. 2006;38:2591–2592. doi: 10.1016/j.transproceed.2006.08.057. - DOI - PubMed
    1. Courneya K.S., Keats M.R., Turner A.R. Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation. [(accessed on 22 August 2019)];Psychooncology. 2000 9:127–136. doi: 10.1002/(SICI)1099-1611(200003/04)9:2<127::AID-PON438>3.0.CO;2-L. Available online: http://www.ncbi.nlm.nih.gov/pubmed/10767750. - DOI - PubMed
    1. Weisdorf D., Haake R., Blazar B., Miller W., McGlave P., Ramsay N., Kersey J., Filipovich A. Treatment of moderate/severe acute graft-versus-host disease after allogeneic bone marrow transplantation: An analysis of clinical risk features and outcome. [(accessed on 27 August 2020)];Blood. 1990 75:1024–1030. doi: 10.1182/blood.V75.4.1024.1024. Available online: https://pubmed.ncbi.nlm.nih.gov/2302454/ - DOI - PubMed
    1. Copelan E.A. Hematopoietic stem-cell transplantation. [(accessed on 27 August 2020)];N. Engl. J. Med. 2006 354:1813–1826. doi: 10.1056/NEJMra052638. Available online: https://pubmed.ncbi.nlm.nih.gov/16641398/ - DOI - PubMed

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