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Review
. 2022 Jan 18;23(3):1011.
doi: 10.3390/ijms23031011.

Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration

Kengo Iwasaki  1 , Yihao Peng  2 , Ryuhei Kanda  1 , Makoto Umeda  2 , Isao Ishikawa  3
Affiliations
Review

Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration

Kengo Iwasaki et al. Int J Mol Sci. .

Abstract

Increasing attention has been paid to cell-based medicines. Many in vivo and in vitro studies have demonstrated the efficacy of stem cell transplantation for the regeneration of periodontal tissues over the past 20 years. Although positive evidence has accumulated regarding periodontal regeneration using stem cells, the exact mechanism of tissue regeneration is still largely unknown. This review outlines the practicality and emerging problems of stem cell transplantation therapy for periodontal regeneration. In addition, possible solutions to these problems and cell-free treatment are discussed.

Keywords: cell transplantation; conditioned medium; exosome; periodontal disease; regeneration.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Darveau R.P. Periodontitis: A polymicrobial disruption of host homeostasis. Nat. Rev. Microbiol. 2010;8:481–490. doi: 10.1038/nrmicro2337. - DOI - PubMed
    1. Pihlstrom B.L., Michalowicz B.S., Johnson N.W. Periodontal diseases. Lancet. 2005;366:1809–1820. doi: 10.1016/S0140-6736(05)67728-8. - DOI - PubMed
    1. Page R.C., Kornman K.S. The pathogenesis of human periodontitis: An introduction. Periodontol. 2000. 1997;14:9–11. doi: 10.1111/j.1600-0757.1997.tb00189.x. - DOI - PubMed
    1. Passarelli P.C., Pagnoni S., Piccirillo G.B., DeSantis V., Benegiamo M., Liguori A., Papa R., Papi P., Pompa G., D’Addona A. Reasons for Tooth Extractions and Related Risk Factors in Adult Patients: A Cohort Study. Int. J. Environ. Res. Public Health. 2020;17:2575. doi: 10.3390/ijerph17072575. - DOI - PMC - PubMed
    1. Beck J., Papapanou P.N., Philips K., Offenbacher S. Periodontal Medicine: 100 Years of Progress. J. Dent. Res. 2019;98:1053–1062. doi: 10.1177/0022034519846113. - DOI - PubMed

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