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Review
. 2022 Jan 20;23(3):1096.
doi: 10.3390/ijms23031096.

Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma

Shinji Miwa  1 , Norio Yamamoto  1 , Katsuhiro Hayashi  1 , Akihiko Takeuchi  1 , Kentaro Igarashi  1 , Hiroyuki Tsuchiya  1
Affiliations
Review

Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma

Shinji Miwa et al. Int J Mol Sci. .

Abstract

Due to resistance to standard anticancer agents, it is difficult to control the disease progression in patients with metastatic or unresectable chondrosarcoma. Novel therapeutic approaches, such as molecule-targeting drugs and immunotherapy, are required to improve clinical outcomes in patients with advanced chondrosarcoma. Recent studies have suggested several promising biomarkers and therapeutic targets for chondrosarcoma, including IDH1/2 and COL2A1. Several molecule-targeting agents and immunotherapies have shown favorable antitumor activity in clinical studies in patients with advanced chondrosarcomas. This review summarizes recent basic studies on biomarkers and molecular targets and recent clinical studies on the treatment of chondrosarcomas.

Keywords: chemotherapy; chondrosarcoma; immunotherapy; therapeutic target.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Murphey M.D., Walker E.A., Wilson A.J., Kransdorf M.J., Temple H.T., Gannon F.H. From the archives of the AFIP: Imaging of primary chondrosarcoma: Radiologic-pathologic correlation. Radiographics. 2003;23:1245–1278. doi: 10.1148/rg.235035134. - DOI - PubMed
    1. WHO Classification of Tumours Editorial Board . WHO Classification of Tumours of Soft Tissue and Bone. 5th ed. IARC Press; Lyon, France: 2020.
    1. Limaiem F., Davis D.D., Sticco K.L. Chondrosarcoma. StatPearls Publishing; Treasure Island, FL, USA: 2022. - PubMed
    1. Grimer R.J., Gosheger G., Taminiau A., Biau D., Matejovsky Z., Kollender Y., San-Julian M., Gherlinzoni F., Ferrari C. Dedifferentiated chondrosarcoma: Prognostic factors and outcome from a European group. Eur. J. Cancer. 2007;43:2060–2065. doi: 10.1016/j.ejca.2007.06.016. - DOI - PubMed
    1. Chow W.A. Chondrosarcoma: Biology, genetics, and epigenetics. F1000 Res. 2018;7:1826. doi: 10.12688/f1000research.15953.1. - DOI - PMC - PubMed

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