Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jan 21;23(3):1153.
doi: 10.3390/ijms23031153.

Modulating mTOR Signaling as a Promising Therapeutic Strategy for Atherosclerosis

Anastasia V Poznyak  1 , Vasily N Sukhorukov  2   3 , Alexander Zhuravlev  2 , Nikolay A Orekhov  1 , Vladislav Kalmykov  2   4 , Alexander N Orekhov  1   2   4
Affiliations
Review

Modulating mTOR Signaling as a Promising Therapeutic Strategy for Atherosclerosis

Anastasia V Poznyak et al. Int J Mol Sci. .

Abstract

For more than a decade, atherosclerosis has been one of the leading causes of death in developed countries. The issue of treatment and prevention of the disease is especially acute. Despite the huge amount of basic and clinical research, a significant number of gaps remain in our understanding of the pathogenesis of atherosclerosis, and only their closure will bring us closer to understanding the causes of the disease at the cellular and molecular levels and, accordingly, to the development of an effective treatment. One of the seemingly well-studied elements of atherogenesis is the mTOR signaling pathway. However, more and more new details are still being clarified. Therapeutic strategies associated with rapamycin have worked well in a number of different diseases, and there is every reason to believe that targeting components of the mTOR pathway may pay off in atherosclerosis as well.

Keywords: atherosclerosis; cardiovascular disease; mTOR; rapamycin.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
mTORC1 and mTORC2 complexes. This scheme represents a simplified structure of mTORC1 and mTORC2 complexes.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Poston R.N. Atherosclerosis: Integration of its pathogenesis as a self-perpetuating propagating inflammation: A review. Cardiovasc. Endocrinol Metab. 2019;2:51–61. doi: 10.1097/XCE.0000000000000172. - DOI - PMC - PubMed
    1. Lappalainen J., Yeung N., Nguyen S.D., Jauhiainen M., Kovanen P.T., Lee-Rueckert M. Cholesterol loading suppresses the atheroinflammatory gene polarization of human macrophages induced by colony stimulating factors. Sci. Rep. 2021;11:4923. doi: 10.1038/s41598-021-84249-y. - DOI - PMC - PubMed
    1. Wilson D.P. Is atherosclerosis a pediatric disease? [Updated 2020] In: Feingold K.R., Anawalt B., Boyce A., editors. Endotext [Internet] MDText.com, Inc.; South Dartmouth, MA, USA: 2000. [(accessed on 17 August 2021)]. Available online: https://www.ncbi.nlm.nih.gov/books/NBK395576/
    1. Asada Y., Yamashita A., Sato Y., Hatakeyama K. Pathophysiology of atherothrombosis: Mechanisms of thrombus formation on disrupted atherosclerotic plaques. Pathol. Int. 2020;70:309–322. doi: 10.1111/pin.12921. - DOI - PMC - PubMed
    1. Lusis A.J. Atherosclerosis. Nature. 2000;407:233–241. doi: 10.1038/35025203. - DOI - PMC - PubMed

MeSH terms