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Review
. 2022 Feb 6;23(3):1840.
doi: 10.3390/ijms23031840.

The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis

Joanna Czerwińska  1 , Agnieszka Owczarczyk-Saczonek  1
Affiliations
Review

The Role of the Neutrophilic Network in the Pathogenesis of Psoriasis

Joanna Czerwińska et al. Int J Mol Sci. .

Abstract

One role of neutrophils, the most abundant innate immune sentinels, is neutrophil extracellular trap (NET) formation, which plays a significant role in immune surveillance. However, NET operation is bidirectional. Recent studies report that NETs may contribute to the development of autoimmune diseases such as psoriasis. The participation of neutrophils in the pathogenesis of that disease is dependent on an autoinflammatory feedback loop between neutrophils, lymphocytes, dendritic cells and keratinocytes. Our aim was to clarify the field of NET research in psoriasis and highlight the main factors required for NET generation, which may be a target of new therapies. This article presents a comphrehensive review concerning studies addressing the participation of neutrophils in the pathogenesis of psoriasis. Based on the available English-language literature, we discuss original papers presenting significant research findings which may help to understand and interpret the NET formation process in psoriasis, as well as the newest systematic reviews on PubMed. Next, the comparison, synthesis and summary of reported results were performed to clearly indicate the specific component of the NET which participates in the development of psoriasis.

Keywords: extracellular trap; neutrophil; neutrophilic network; psoriasis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The process of NET creation.
Figure 2
Figure 2
The autoinflammatory feedback loop between neutrophils, dendritic cells, lymphocytes and keratinocytes in psoriasis.
See this image and copyright information in PMC

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