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Review
. 2022 Feb 8;23(3):1919.
doi: 10.3390/ijms23031919.

Interactions between Radiation and One-Carbon Metabolism

Navyateja Korimerla  1   2 , Daniel R Wahl  1   2
Affiliations
Review

Interactions between Radiation and One-Carbon Metabolism

Navyateja Korimerla et al. Int J Mol Sci. .

Abstract

Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism. This review discusses the interactions between radiation therapy, one-carbon metabolism and its component metabolic pathways.

Keywords: cancer therapy; folate cycle; methionine cycle; one-carbon metabolism; radiation therapy.

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Conflict of interest statement

D.R.W. has previously received research funding from Agios/Servier related to the content of this manuscript.

Figures

Figure 1
Figure 1
Overview of radiation-induced changes in one-carbon metabolism. Enzymes, metabolites and pathways affected by radiation directly or indirectly are highlighted in the figure. Dihydrofolate (DHF), Tetrahydrofolate (THF), serine hydroxymethyltransferase (SHMT), 10-formyltetrahydrofolate (10-fTHF), 5-methyltetrahydrofolate (5-mTHF) methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS), methionine adenosyltransferase 2A (MAT2A), S-adenosylmethionine (SAM), methyltransferases(MT), S-adenosylhomocysteine (SAH), adenosylhomocysteinase (ACHY), methylthioadenosine phosphorylase (MTAP), 5′-Methylthioadenosine (MTA), 5-deoxy-5-(methylthio)ribose (MTR), betaine-homocysteine methyltransferase (BHMT), homocysteine (HCY), cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE). Enzymes, metabolites and pathways affected by radiation directly/indirectly are highlighted in red.
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