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Review
. 2022 Jan 21;27(3):700.
doi: 10.3390/molecules27030700.

Modeling Postmortem Ethanol Production/Insights into the Origin of Higher Alcohols

Vassiliki A Boumba  1
Affiliations
Review

Modeling Postmortem Ethanol Production/Insights into the Origin of Higher Alcohols

Vassiliki A Boumba. Molecules. .

Abstract

The forensic toxicologist is challenged to provide scientific evidence to distinguish the source of ethanol (antemortem ingestion or microbial production) determined in the postmortem blood and to properly interpret the relevant blood alcohol concentration (BAC) results, in regard to ethanol levels at death and subsequent behavioral impairment of the person at the time of death. Higher alcohols (1-propanol, 1-butanol, isobutanol, 2-methyl-1-butanol (isoamyl-alcohol), and 3-methyl-2-butanol (amyl-alcohol)) are among the volatile compounds that are often detected in postmortem specimens and have been correlated with putrefaction and microbial activity. This brief review investigates the role of the higher alcohols as biomarkers of postmortem, microbial ethanol production, notably, regarding the modeling of postmortem ethanol production. Main conclusions of this contribution are, firstly, that the higher alcohols are qualitative and quantitative indicators of microbial ethanol production, and, secondly that the respective models of microbial ethanol production are tools offering additional data to interpret properly the origin of the ethanol concentrations measured in postmortem cases. More studies are needed to clarify current uncertainties about the origin of higher alcohols in postmortem specimens.

Keywords: biomarker; blood alcohol concentration (BAC); congener alcohol; ethanol analysis; higher alcohol; modeling; postmortem.

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Conflict of interest statement

The author declares no conflict of interest.

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References

    1. Wigmore J.G. Wigmore on Alcohol: Courtroom Alcohol Toxicology for the Medicolegal Professional. 1st ed. Irwin Law; Toronto, ON, Canada: 2011.
    1. Ziavrou K., Boumba V.A., Vougiouklakis T.G. Insights into the origin of postmortem ethanol. Int. J. Toxicol. 2005;24:69–77. doi: 10.1080/10915810590936391. - DOI - PubMed
    1. Kugelberg F.C., Jones A.W. Interpreting results of ethanol analysis in postmortem specimens: A review of the literature. Forensic Sci. Int. 2007;165:10–29. doi: 10.1016/j.forsciint.2006.05.004. - DOI - PubMed
    1. Dinis-Oliveira R.J. The auto-brewery syndrome: A perfect metabolic “storm” with clinical and forensic implications. J. Clin. Med. 2021;10:4637. doi: 10.3390/jcm10204637. - DOI - PMC - PubMed
    1. Cowan D.M., Maskrey J.R., Fung E.S., Scott P.K., Finley B.L. Best-practices approach to determination of blood alcohol concentration (BAC) at specific time points: Combination of ante-mortem alcohol pharmacokinetic modeling and post-mortem alcohol generation and transport considerations. Regul. Toxicol. Pharmacol. 2016;78:24–36. doi: 10.1016/j.yrtph.2016.03.020. - DOI - PubMed

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