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Review
. 2022 Jan 26;27(3):811.
doi: 10.3390/molecules27030811.

SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression

Nouralhuda Alateyah  1 , Ishita Gupta  2   3 , Radoslaw Stefan Rusyniak  1 , Allal Ouhtit  1
Affiliations
Review

SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression

Nouralhuda Alateyah et al. Molecules. .

Abstract

CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44's gene in the breast cancer (BC) cell line MCF-7 (B5 clone). Using cDNA oligo gene expression microarray, we identified SOD2 (superoxide dismutase 2) as a potential CD44-downstream transcriptional target involved in BC metastasis. SOD2 gene belongs to the family of iron/manganese superoxide dismutase family and encodes a mitochondrial protein. SOD2 plays a role in cell proliferation and cell invasion via activation of different signaling pathways regulating angiogenic abilities of breast tumor cells. This review will focus on the findings supporting the underlying mechanisms associated with the oncogenic potential of SOD2 in the onset and progression of cancer, especially in BC and the potential clinical relevance of its various inhibitors.

Keywords: CD44; SOD2; breast cancer; hyaluronan; invasion.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
A proposed novel model of the molecular signaling pathways that link the activation of CD44 by its ligand hyaluronan (HA) to the transactivation of its potential target gene SOD2.
See this image and copyright information in PMC

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