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. 2022 Feb 14;15(1):46.
doi: 10.1186/s13104-022-05918-3.

Association of DNA repair genes polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis

Shahrzad Zehtab  1 , Mahla Sattarzadeh Bardsiri  1   2 , Roohollah Mirzaee Khalilabadi  1 , Mohsen Ehsan  1 , Ahmad Fatemi  3   4
Affiliations

Association of DNA repair genes polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis

Shahrzad Zehtab et al. BMC Res Notes. .

Abstract

Objective: Acute lymphoblastic leukemia (ALL) is one of the most common cancers in children for which the exact pathogenesis is not yet known. Single-nucleotide variants (SNVs) in different DNA repair genes are reported to be associated with ALL risk. This study aimed to determine the association between XRCC1 (rs1799782) and NBN (rs1805794, rs709816) SNVs and childhood ALL risk in a sample of the Iranian population. Fifty children with ALL and 50 age- and sex-matched healthy children were included in this case-control study. Genotyping of the mentioned SNVs was done by high-resolution melting (HRM) analysis.

Results: The prevalence of all three SNVs in XRCC1 and NBN genes did not differ between the patient and control groups, and these polymorphisms were not associated with childhood ALL risk (P > 0.05). HRM was a practical method for the detection of SNVs in XRCC1 and NBN genes. We found no significant association between XRCC1 (rs1799782) and NBN (rs1805794, rs709816) SNVs and childhood ALL risk.

Keywords: Childhood acute lymphoblastic Leukemia; High-resolution melting analysis; NBN; Single nucleotide variants; XRCC1.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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