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Comment
. 2022 Apr;18(4):207-208.
doi: 10.1038/s41581-022-00549-0.

Kidneys control inter-organ homeostasis

Victor G Puelles  1 , Tobias B Huber  2
Affiliations
Comment

Kidneys control inter-organ homeostasis

Victor G Puelles et al. Nat Rev Nephrol. 2022 Apr.

Abstract

Cockayne syndrome is a genetic disease characterized by impairment of DNA repair mechanisms, premature ageing, cachexia and kidney dysfunction. New research in a mouse model of Cockayne syndrome demonstrates that injury induces a subset of kidney proximal tubule cells to express the anorexigenic peptide GDF15. These findings link kidney injury to cachexia and highlight the role of the kidney in mediating inter-organ homeostasis.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Kidneys control organ homeostasis.
Kidney injury can induce the production of anorexic and muscle-wasting signals from various cell populations, resulting in cachexia.
See this image and copyright information in PMC

Comment on

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