Targeting microbial metabolites to treat autism

Rochellys Diaz Heijtz^{1

2}, Pierre Gressens^{3

4}, Jonathan R Swann^{3

5}

Affiliations

¹ Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden. rochellys.heijtz@ki.se.
² University of Rouen Normandy, INSERM U1239, Rouen, France. rochellys.heijtz@ki.se.
³ Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden.
⁴ Université de Paris, NeuroDiderot, Inserm, Paris, France.
⁵ School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

Comment

Rochellys Diaz Heijtz et al. Nat Med. 2022 Mar.

. 2022 Mar;28(3):448-450.

doi: 10.1038/s41591-022-01711-8.

Rochellys Diaz Heijtz^{1

2}, Pierre Gressens^{3

4}, Jonathan R Swann^{3

5}

¹ Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden. rochellys.heijtz@ki.se.
² University of Rouen Normandy, INSERM U1239, Rouen, France. rochellys.heijtz@ki.se.
³ Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden.
⁴ Université de Paris, NeuroDiderot, Inserm, Paris, France.
⁵ School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.

No abstract available

Comment on

A gut-derived metabolite alters brain activity and anxiety behaviour in mice.
Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, Wu WL, Rabut C, Ladinsky MS, Hwang SJ, Guo Y, Zhu Q, Griffiths JA, Knight R, Bjorkman PJ, Shapiro MG, Geschwind DH, Holschneider DP, Fischbach MA, Mazmanian SK. Needham BD, et al. Nature. 2022 Feb;602(7898):647-653. doi: 10.1038/s41586-022-04396-8. Epub 2022 Feb 14. Nature. 2022. PMID: 35165440 Free PMC article.
Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial.
Stewart Campbell A, Needham BD, Meyer CR, Tan J, Conrad M, Preston GM, Bolognani F, Rao SG, Heussler H, Griffith R, Guastella AJ, Janes AC, Frederick B, Donabedian DH, Mazmanian SK. Stewart Campbell A, et al. Nat Med. 2022 Mar;28(3):528-534. doi: 10.1038/s41591-022-01683-9. Epub 2022 Feb 14. Nat Med. 2022. PMID: 35165451 Clinical Trial.

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