Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr;72(4):267-269.
doi: 10.1111/pin.13214. Epub 2022 Feb 14.

C4d deposition and CD39 downregulation in the placental infection by SARS-CoV-2

Affiliations

C4d deposition and CD39 downregulation in the placental infection by SARS-CoV-2

Yoshiya Shimao et al. Pathol Int. 2022 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
(a) Cut surface of the placenta, (b) histological findings of the placental tissue, (c) anti‐CD68 immunostaining, (d) anti‐spike protein for severe acute respiratory syndrome coronavirus 2, (e) andi‐complement deposition immunostaining, (f) anti‐CD39 immunostaining

Similar articles

Cited by

References

    1. Schwartz DA, Baldewijns M, Benachi A, Bugatti M, Collins RRJ, De Luca D, et al. Chronic histiocytic intervillositis with trophoblast necrosis is a risk factor associated with placental infection from coronavirus disease 2019 (COVID‐19) and intrauterine maternal‐fetal severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission in live‐born and stillborn infants. Arch Pathol Lab Med. 2021;145(5):517–28. 10.5858/arpa.2020-0771-SA - DOI - PubMed
    1. Roberts DJ, Edlow AG, Romero RJ, Coyne CB, Ting DT, Hornick JL, et al. A standardized definition of placental infection by SARS‐CoV‐2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS‐CoV‐2 Placental Infection Workshop. Am J Obstet Gynecol. 2021;225(6):593.e1–e9. 10.1016/j.ajog.2021.07.029 - DOI - PMC - PubMed
    1. Watkins JC, Torous VF, Roberts DJ. Defining severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) placentitis. Arch Pathol Lab Med. 2021;145(11):1341–49. 10.5858/arpa.2021-0246-SA - DOI - PubMed
    1. Sato Y, Maekawa K, Aman M, Yamashita A, Kodama Y, Maki Y, et al. CD39 downregulation in chronic intervillositis of unknown etiology. Virchows Arch. 2019;475(3):357–64. 10.1007/s00428-019-02598-6 - DOI - PubMed
    1. Debelenko L, Katsyv I, Chong AM, Peruyero L, Szabolcs M, Uhlemann AC. Trophoblast damage with acute and chronic intervillositis: disruption of the placental barrier by severe acute respiratory syndrome coronavirus 2. Hum Pathol. 2021;109:69–79. 10.1016/j.humpath.2020.12.004 - DOI - PMC - PubMed