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Meta-Analysis
. 2022 Feb 15;60(5):786-792.
doi: 10.1515/cclm-2021-1331. Print 2022 Apr 26.

Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis

Luisa Agnello  1 , Matteo Vidali  2 , Bruna Lo Sasso  1   3 , Rosaria Vincenza Giglio  1   3 , Caterina Maria Gambino  1   3 , Concetta Scazzone  1 , Anna Maria Ciaccio  4 , Giulia Bivona  1 , Marcello Ciaccio  1   3
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Free article
Meta-Analysis

Monocyte distribution width (MDW) as a screening tool for early detecting sepsis: a systematic review and meta-analysis

Luisa Agnello et al. Clin Chem Lab Med. .
Free article

Abstract

Objectives: Monocyte distribution has recently emerged as a promising biomarker of sepsis, especially in acute setting, such as Emergency Department and Intensive Care Unit. This study aimed to evaluate the accuracy of monocyte distribution width (MDW) for early detecting patients with sepsis by performing a systemic review and meta-analysis of published studies.

Methods: Relevant publications were identified by a systematic literature search on PubMed and Google Scholar from inception to September 07, 2021. Studies were divided into two groups based on the sepsis criteria applied, namely sepsis-2 or sepsis-3.

Results: Ten studies including 9,475 individuals, of whom 1,370 with sepsis (742 according Sepsis-2 and 628 according to Sepsis-3), met the inclusion criteria for our meta-analysis. The pooled sensitivity and specificity were 0.789 and 0.777 for Sepsis-2 criteria, 0.838 and 0.704 for Sepsis-3 criteria.

Conclusions: MDW represents a reliable biomarker for sepsis screening.

Keywords: biomarker; monocyte distribution (MDW); monocytes; screening; sepsis.

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