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Multicenter Study
. 2023 May 1;277(5):e1130-e1137.
doi: 10.1097/SLA.0000000000005409. Epub 2023 Apr 6.

Treatment and Outcomes of Congenital Ovarian Cysts A Study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)

Nadia Safa  1 , Natalie Yanchar  2 , Pramod Puligandla  1 , Maida Sewitch  2 , Robert Baird  3 , Mona Beaunoyer  4 , Niamh Campbell  5 , Rati Chadha  6 , Christopher Griffiths  7 , Sarah Jones  2 , Manvinder Kaur  8 , Annie Le-Nguyen  4 , Ahmed Nasr  8 , Nelson Piché  4 , Hannah Piper  3 , Pascale Prasil  9 , Rodrigo L P Romao  5 , Lisa VanHouwelingen  7 , Paul Wales  10 , Elena Guadagno  1 , Sherif Emil  1 ; Canadian Consortium for Research in Pediatric Surgery (CanCORPS)
Affiliations
Multicenter Study

Treatment and Outcomes of Congenital Ovarian Cysts A Study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)

Nadia Safa et al. Ann Surg. .

Abstract

Objective: We conducted a multicenter study to assess treatments and outcomes in a national cohort of infants with congenital ovarian cysts.

Summary background data: Wide variability exists in the treatment of congenital ovarian cysts. The effects of various treatment strategies on outcomes, specifically ovarian preservation, are not known.

Methods: Female infants diagnosed with congenital intra-abdominal cysts between 2013 and 2017 at 10 Canadian pediatric surgical centers were retrospectively evaluated. Sonographic characteristics, median time to cyst resolution, incidence of ovarian preservation, and predictors of surgery were evaluated. Subgroup analyses were performed in patients with complex cysts and cysts ≥40 mm in diameter.

Results: The study population included 189 neonates. Median gestational age at diagnosis and median maximal prenatal cyst diameter were 33 weeks and 40 mm, respectively. Cysts resolved spontaneously in 117 patients (62%), 14 (7%) prenatally, and the remainder at a median age of 124 days. Intervention occurred in 61 patients (32%), including prenatal aspiration (2, 3%), ovary sparing resection (14, 23%), or oophorectomy (45, 74%). Surgery occurred at a median age of 7.4weeks. Independent predictors of surgery included postnatal cyst diameter ≥40 mm [odds ratio (OR) 6.19, 95% confidence interval (CI) 1.66-35.9] and sonographic complex cyst character (OR 63.6, 95% CI 10.9-1232). There was no significant difference in the odds of ovarian preservation (OR 3.06, 95% CI 0.86 -13.2) between patients who underwent early surgery (n = 22) and those initially observed for at least 3 months (n = 131).

Conclusions: Most congenital ovarian cysts are asymptomatic and spontaneously resolve. Early surgical intervention does not increase ovarian preservation.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Management and outcomes of patients with congenital ovarian cysts (N = 189).
Figure 2
Figure 2
Kaplan−meier survival analysis of time to resolution.
Figure 3
Figure 3
Management guideline for patients with congenital ovarian cysts.
See this image and copyright information in PMC

References

    1. Trinh TW, Kennedy AM. Fetal ovarian cysts: review of imaging spectrum, differential diagnosis, management, and outcome. Radiographics. 2015;35:621–635. - PubMed
    1. Kirkinen P, Jouppila P. Perinatal aspects of pregnancy complicated by fetal ovarian cyst. J Perinat Med. 1985;13:245–251. - PubMed
    1. Bagolan P, Rivosecchi M, Giorlandino C, et al. . Prenatal diagnosis and clinical outcome of ovarian cysts. J Pediatr Surg. 1992;27:879–881. - PubMed
    1. Giorlandino C, Bilancioni E, Bagolan P, et al. . Antenatal ultrasonographic diagnosis and management of fetal ovarian cysts. Int J Gynaecol Obstet. 1993;44:27–31. - PubMed
    1. Cesca E, Midrio P, Boscolo-Berto R, et al. . Conservative treatment for complex neonatal ovarian cysts: a long-term follow-up analysis. J Pediatr Surg. 2013;48:510–515. - PubMed

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