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. 2022 Mar;32(2):173-180.
doi: 10.1111/vec.13155. Epub 2022 Feb 15.

Comparison of point-of-care NOVA CCX blood gas analyzer to laboratory analyzer in a population of healthy adult cats

H Nicole Trenholme  1   2 , Beth Tynan  1   3 , Mary Jackson  1   4 , Marie Kerl  1   5
Affiliations

Comparison of point-of-care NOVA CCX blood gas analyzer to laboratory analyzer in a population of healthy adult cats

H Nicole Trenholme et al. J Vet Emerg Crit Care (San Antonio). 2022 Mar.

Abstract

Objective: To compare the level of agreement of measurement of analytes (sodium, chloride, potassium, urea nitrogen [UN], creatinine, glucose) in a population of healthy adult cats between the point-of-care (POC) analyzer and laboratory analyzer. To establish reference intervals for the POC analyzer in healthy adult cats.

Design: Prospective observational study.

Setting: University teaching hospital.

Animals: Fifty-five cats were screened. Seven cats were excluded due to aggression that prohibited phlebotomy, and 1 cat was excluded due to prolonged restraint; 47 cats were enrolled.

Interventions: None.

Measurements and main results: In this patient population, reference intervals for the POC analyzer were calculated: sodium 145-157 mmol/L; chloride 116-124 mmol/L; potassium 3.4-5.5 mmol/L; UN 5.71-13.9 mmol/L (16-39 mg/dl); creatinine 74.3-189.2 mmol/L (0.84-2.14 mg/dl); and glucose 4-11.8 mmol/L (72-213 mg/dl). Comparison between the POC analyzer and laboratory analyzer using the Bland-Altman method was performed. The bias for each analyte is as follows: sodium 1.55 mmol/L; chloride 0.99 mmol/L; potassium 0.21 mmol/L; UN -0.25 mmol/L (-0.7 mg/dl); creatinine 9.73 mmol/L (0.11 mg/dl); and glucose 0.5 mmol/L (9.79 mg/dl).

Conclusions: Reference intervals for each analyte were similar to other chemistry analyzers. There was no significant difference between the POC and laboratory analyzers in analysis of UN, with a statistically significant difference observed with sodium, potassium, chloride, creatinine, and glucose. However, the values are likely not sufficiently different to alter initial clinical decisions regarding patient care.

Keywords: critical care; electrolytes; point-of-care; reference interval.

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References

REFERENCES

    1. Morimatsu H, Rocktaschel J, Bellomo R, et al. Comparison of point-of-care versus central laboratory measurement of electrolyte concentrations on calculations of the anion gap and the strong ion difference. Anesthesiology. 2003;98(5):1077-1084.
    1. Vanavanan S, Chittamma A. Performance of a multi-profile critical care testing analyzer. Clin Chem Lab Med. 2008;46(1):9-14.
    1. Calzavacca P, Tee A, Licari E, et al. Point-of-care measurement of serum creatinine in the intensive care unit. Ren Fail. 2012;34(1):13-18.
    1. Flegar-Mestric Z, Perkov S. Comparability of point-of-care whole-blood electrolyte and substrate testing using a Stat Profile Critical Care Xpress analyzer and standard laboratory methods. Clin Chem Lab Med. 2006;44(7):898-903.
    1. Yip PM, Venner AA, Shea J, et al. Point-of-care testing: a position statement from the Canadian Society of Clinical Chemists. Clin Biochem. 2018;53:156-159.

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