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. 2022 Feb 1;5(2):e220460.
doi: 10.1001/jamanetworkopen.2022.0460.

Updated US Prevalence Estimates for Chronic Kidney Disease Stage and Complications Using the New Race-Free Equation to Estimate Glomerular Filtration Rate

Carl P Walther  1 , Wolfgang C Winkelmayer  1 , Sankar D Navaneethan  1   2   3
Affiliations

Updated US Prevalence Estimates for Chronic Kidney Disease Stage and Complications Using the New Race-Free Equation to Estimate Glomerular Filtration Rate

Carl P Walther et al. JAMA Netw Open. .

Abstract

This cross-sectional study investigates US population changes in chronic kidney disease (CKD) G stage and 4 CKD-related complications, comparing the 2021 equation for estimating glomerular filtration rate with the 2009 equation, which included a race coefficient.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Winkelmayer reported receiving personal fees from Akebia/Otsuka, AstraZeneca, Bayer, Boehringer Ingelheim and Eli Lilly and Co, Janssen Pharmaceuticals, Merck, Pharmacosmos, Reata, and Relypsa outside the submitted work. Dr Navaneethan reported receiving personal fees from Bayer, Boehringer Ingelheim and Eli Lilly and Co, Vifor, and Tricida; receiving grants from Keryx; and receiving research funding from the Department of Veterans Affairs Health Services Research & Development outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Estimated Glomerular Filtration Rate (eGFR) Category Change Estimates in the US Population From Chronic Kidney Disease (CKD)–Epidemiology Collaboration 2009 Equation to 2021 Equation
The vertical widths of the bands represent proportions of individuals in (left axis) eGFR categories according to the 2009 equation, (right axis) eGFR categories according to the 2021 equation, and (middle) proportions belonging to connected left and right axis groups. Classifications use the Kidney Disease: Improving Global Outcomes CKD G classifications, based on eGFR, as follows: G1 or G2, 60 mL/min/1.73 m2 or greater; G3a, 45 to 59 mL/min/1.73 m2; G3b, 30 to 44 mL/min/1.73 m2; G4, 15 to 29 mL/min/1.73 m2; and G5, less than 15 mL/min/1.73 m2.
See this image and copyright information in PMC

References

    1. Powe NR. Black kidney function matters: use or misuse of race? JAMA. 2020;324(8):737-738. doi:10.1001/jama.2020.13378 - DOI - PubMed
    1. Inker LA, Eneanya ND, Coresh J, et al. . New creatinine-and cystatin C–based equations to estimate GFR without race. N Engl J Med. 2021;385:1737-1749. doi:10.1056/NEJMoa2102953 - DOI - PMC - PubMed
    1. Delgado C, Baweja M, Crews DC, et al. . A unifying approach for GFR estimation: recommendations of the NKF-ASN task force on reassessing the inclusion of race in diagnosing kidney disease. Am J Kidney Dis. Published online September 23, 2021. doi:10.1053/j.ajkd.2021.08.003 - DOI - PubMed
    1. Inker LA, Coresh J, Levey AS, Tonelli M, Muntner P. Estimated GFR, albuminuria, and complications of chronic kidney disease. J Am Soc Nephrol. 2011;22(12):2322-2331. doi:10.1681/ASN.2010111181 - DOI - PMC - PubMed
    1. US Centers for Disease Control and Prevention . NHANES survey methods and analytic guidelines. Accessed January 18, 2022. https://wwwn.cdc.gov/nchs/nhanes/analyticguidelines.aspx

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