The role of ferroptosis in acute lung injury
- PMID: 35166985
- PMCID: PMC8853161
- DOI: 10.1007/s11010-021-04327-7
The role of ferroptosis in acute lung injury
Abstract
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common disease with high morbidity and mortality, and its pathogenesis is believed to be related to oxidative stress, apoptosis, inflammation, and hypoxia. Ferroptosis is a type of nonapoptotic cell death characterized by iron-dependent lipid peroxide accumulation and is involved in many cellular physiological processes. Recent studies have confirmed that ferroptosis may be involved in the development of ALI. This review summarizes the most recent discoveries on the role of ferroptosis in ALI to provide new strategies for its prevention and treatment.
Keywords: Acute lung injury; Ferroptosis; Glutathione peroxidase 4; Lipid peroxidation.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Conflict of interest statement
The authors declare that they have no conflict of interest.
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