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Review
. 2022 Jan;23(1):68-77.
doi: 10.1007/s11864-022-00943-7. Epub 2022 Feb 15.

Preoperative Radiation for Soft Tissue Sarcomas: How Much Is Needed?

Safia K Ahmed  1 , Ivy A Petersen  2
Affiliations
Review

Preoperative Radiation for Soft Tissue Sarcomas: How Much Is Needed?

Safia K Ahmed et al. Curr Treat Options Oncol. 2022 Jan.

Abstract

Preoperative radiation therapy is an important component of curative treatment for extremity and superficial trunk soft tissue sarcomas. It has traditionally been delivered to a dose of 50 Gy in 2 Gy fractions over 5 weeks. With significant advances in the multidisciplinary approach to soft tissue sarcomas, preoperative radiation therapy may be omitted for certain cases, delivered over a shortened period of time (1-3 weeks), deintensified for myxoid liposarcomas, or combined with systemic therapy to improve the therapeutic ratio. This article reviews the innovative preoperative radiation therapy strategies currently used to treat extremity and superficial trunk soft tissue sarcomas.

Keywords: Combination therapy; Dose deintensification; Hypofractionation; Omission of radiation therapy; Preoperative radiation therapy; Soft tissue sarcoma.

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References

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance
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