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. 2022 Feb 14;40(2):125-127.
doi: 10.1016/j.ccell.2022.01.014.

Lactobacillus reuteri-an old acquaintance takes on a new task in colorectal tumor surveillance

Christina Watschinger  1 , Alexander R Moschen  2
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Lactobacillus reuteri-an old acquaintance takes on a new task in colorectal tumor surveillance

Christina Watschinger et al. Cancer Cell. .
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Abstract

In this issue of Cancer Cell, Bell et al. identify the commensal bacterium Lactobacillus reuteri and its major metabolite reuterin as an important gatekeeper and promising target in colorectal cancerogenesis. They decipher a metabolic interplay in which L. reuteri is suppressed by metabolites from dysplastic intestinal epithelial cells which in turn are highly sensitive to the oxidative effects of the electrophile reuterin.

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Conflict of interest statement

Declaration of interests C.W. declares no competing interests. A.R.M. is receiving research support under the framework of the Christian Doppler Research Society from AbbVie and Takeda.

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