Eu doped Ti3C2 quantum dots to form a ratiometric fluorescence platform for visual and quantitative point-of-care testing of tetracycline derivatives

Abstract

Antibiotic residues have become a public health issues, the fast detection of tetracycline (Tc) in the environment is urgently required. In this work, Ti₃C₂ quantum dots (Ti₃C₂ QDs) and Europium ions jointly constructed a ratiometric fluorescence (FL) platform for the detection of Tc, based on synergistic impact of the Foster Resonance Energy Transfer (FRET) from Ti₃C₂ QDs to Eu³⁺ ions and the Antenna Effect (AE) between Tc and Eu³⁺ ions. And we proposed a ratiometric FL platform for detecting Tc with good linear response range (100-1000 uM) and low detection limit (48.79 nM). Meanwhile, we applied this platform to detect a serious of β-diketone ligands of Eu³⁺ ions, demonstrating the platform's versatility for this category of chemical. Furthermore, based on the color changes of QDs@Eu³⁺ from blue to red at 365 nm ultraviolet light, an intelligent detection smart device was built for the visual semi-quantitative detection of Tc in actual samples. We proved the applicability of the device in complicated samples and the potential for rapid, sensitive, intuitive and point-of-care detection in the field of environment, food, pharmaceutical and agriculture.

Keywords: MXene; Ratiometric fluorescence platform; Tetracycline; Ti(3)C(2) quantum dots.