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. 2022 Mar:211:150-153.
doi: 10.1016/j.thromres.2022.01.023. Epub 2022 Jan 29.

Potentially inappropriate prescribing of DOACs to people with mechanical heart valves: A federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY

OpenSAFELY Collaborative; Louis Fisher  1 , Victoria Speed  2 , Helen J Curtis  1 , Christopher T Rentsch  3 , Angel Y S Wong  3 , Anna Schultze  3 , Jon Massey  1 , Peter Inglesby  1 , Caroline E Morton  1 , Marion Wood  4 , Alex J Walker  1 , Jessica Morley  1 , Amir Mehrkar  1 , Seb Bacon  1 , George Hickman  1 , Chris Bates  5 , Richard Croker  1 , David Evans  1 , Tom Ward  1 , Jonathan Cockburn  6 , Simon Davy  1 , Krishnan Bhaskaran  3 , Becky Smith  1 , Elizabeth Williamson  3 , William Hulme  1 , Amelia Green  1 , Rosalind M Eggo  3 , Harriet Forbes  6 , John Tazare  3 , John Parry  5 , Frank Hester  5 , Sam Harper  5 , Jonathan Meadows  7 , Shaun O'Hanlon  7 , Alex Eavis  7 , Richard Jarvis  7 , Dima Avramov  7 , Paul Griffiths  7 , Aaron Fowles  7 , Nasreen Parkes  7 , Ian J Douglas  3 , Stephen J W Evans  3 , Liam Smeeth  3 , Brian MacKenna  8 , Laurie Tomlinson  3 , Ben Goldacre  9
Affiliations

Potentially inappropriate prescribing of DOACs to people with mechanical heart valves: A federated analysis of 57.9 million patients' primary care records in situ using OpenSAFELY

OpenSAFELY Collaborative et al. Thromb Res. 2022 Mar.
No abstract available

Keywords: Anticoagulants; Electronic health records; Heart valve prosthesis; Patient safety; Thrombosis.

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Conflict of interest statement

Conflicts of Interest

All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare the following: over the past five years BG has received research funding from the Laura and John Arnold Foundation, the NHS National Institute for Health Research (NIHR), the NIHR School of Primary Care Research, the NIHR Oxford Biomedical Research Centre, the Mohn-Westlake Foundation, NIHR Applied Research Collaboration Oxford and Thames Valley, the Wellcome Trust, the Good Thinking Foundation, Health Data Research UK (HDRUK), the Health Foundation, and the World Health Organisation; he also receives personal income from speaking and writing for lay audiences on the misuse of science. BMK is also employed by NHS England working on medicines policy and clinical lead for primary care medicines data. KB holds a Sir Henry Dale fellowship jointly funded by Wellcome and the Royal Society (107731/Z/15/Z). AYSW holds a fellowship from the British Heart Foundation. EJW holds grants from MRC. HF holds a UKRI fellowship. IJD has received unrestricted research grants and holds shares in GlaxoSmithKline (GSK).

Figures

Figure 1
Figure 1. The monthly number of people with a record of a mechanical valve who are also prescribed a DOAC between January 2019 and December 2021.
See this image and copyright information in PMC

References

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