Lifestyle predictors for inconsistent participation to fecal based colorectal cancer screening

Markus Dines Knudsen^{1

2

3}, Ane Sørlie Kvaerner⁴, Edoardo Botteri^{4

5}, Øyvind Holme^{6

7}, Anette Hjartåker⁸, Mingyang Song^{9

10

11

12}, Espen Thiis-Evensen¹³, Kristin Ranheim Randel⁴, Geir Hoff^{4

7

14}, Paula Berstad⁴

Affiliations

¹ Section for Colorectal Cancer Screening, Cancer Registry of Norway, P.O. Box 5313, 0304, Majorstuen, Oslo, Norway. markus.knudsen@kreftregisteret.no.
² Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Norwegian PSC Research Center, Oslo University Hospital, P.O. Box 4950, 0424, Rikshospitalet, Nydalen, Oslo, Norway. markus.knudsen@kreftregisteret.no.
³ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA. markus.knudsen@kreftregisteret.no.
⁴ Section for Colorectal Cancer Screening, Cancer Registry of Norway, P.O. Box 5313, 0304, Majorstuen, Oslo, Norway.
⁵ Department of Research, Cancer Registry of Norway, P.O. Box 5313, 0304, Majorstuen, Oslo, Norway.
⁶ Department of Medicine, Sørlandet Hospital Kristiansand, P.O. Box 416, 4604, Lundsiden, Kristiansand, Norway.
⁷ Department of Health Management and Health Economis, Institute of Health and Society, University of Oslo, P.O. Box 1089, 0317, Blindern, Oslo, Norway.
⁸ Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, 0317, Blindern, Oslo, Norway.
⁹ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA.
¹⁰ Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
¹¹ Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
¹² Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, USA.
¹³ Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Norwegian PSC Research Center, Oslo University Hospital, P.O. Box 4950, 0424, Rikshospitalet, Nydalen, Oslo, Norway.
¹⁴ Department of Research and Development, Telemark Hospital Trust, Ulefossvegen 55, 3710, Skien, Norway.

PMID: 35168592
PMCID: PMC8848967
DOI: 10.1186/s12885-022-09287-9

Lifestyle predictors for inconsistent participation to fecal based colorectal cancer screening

Markus Dines Knudsen et al. BMC Cancer. 2022.

. 2022 Feb 15;22(1):172.

doi: 10.1186/s12885-022-09287-9.

Authors

Affiliations

¹ Section for Colorectal Cancer Screening, Cancer Registry of Norway, P.O. Box 5313, 0304, Majorstuen, Oslo, Norway. markus.knudsen@kreftregisteret.no.
² Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Norwegian PSC Research Center, Oslo University Hospital, P.O. Box 4950, 0424, Rikshospitalet, Nydalen, Oslo, Norway. markus.knudsen@kreftregisteret.no.
³ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA. markus.knudsen@kreftregisteret.no.
⁴ Section for Colorectal Cancer Screening, Cancer Registry of Norway, P.O. Box 5313, 0304, Majorstuen, Oslo, Norway.
⁵ Department of Research, Cancer Registry of Norway, P.O. Box 5313, 0304, Majorstuen, Oslo, Norway.
⁶ Department of Medicine, Sørlandet Hospital Kristiansand, P.O. Box 416, 4604, Lundsiden, Kristiansand, Norway.
⁷ Department of Health Management and Health Economis, Institute of Health and Society, University of Oslo, P.O. Box 1089, 0317, Blindern, Oslo, Norway.
⁸ Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P.O. Box 1046, 0317, Blindern, Oslo, Norway.
⁹ Departments of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 02115, Boston, MA, USA.
¹⁰ Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
¹¹ Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA.
¹² Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, USA.
¹³ Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Norwegian PSC Research Center, Oslo University Hospital, P.O. Box 4950, 0424, Rikshospitalet, Nydalen, Oslo, Norway.
¹⁴ Department of Research and Development, Telemark Hospital Trust, Ulefossvegen 55, 3710, Skien, Norway.

PMID: 35168592
PMCID: PMC8848967
DOI: 10.1186/s12885-022-09287-9

Abstract

Background: Consistent participation in colorectal cancer (CRC) screening with repeated fecal immunochemical test (FIT) is important for the success of the screening program. We investigated whether lifestyle risk factors for CRC were related to inconsistent participation in up to four rounds of FIT-screening.

Method: We included data from 3,051 individuals who participated in up to four FIT-screening rounds and returned a lifestyle questionnaire. Using logistic regression analyses, we estimated associations between smoking habits, body mass index (BMI), physical activity, alcohol consumption, diet and a healthy lifestyle score (from least favorable 0 to most favorable 5), and inconsistent participation (i.e. not participating in all rounds of eligible FIT screening invitations).

Results: Altogether 721 (24%) individuals were categorized as inconsistent participants Current smoking and BMI ≥30 kg/m² were associated with inconsistent participation; odds ratios (ORs) and 95% confidence intervals (CIs) were 1.54 (1.21-2.95) and 1.54 (1.20-1.97), respectively. A significant trend towards inconsistent participation by a lower healthy lifestyle score was observed (p < 0.05).

Conclusions: Lifestyle behaviors were associated with inconsistent participation in FIT-screening. Initiatives aimed at increasing participation rates among those with the unhealthiest lifestyle have a potential to improve the efficiency of screening.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

**Fig. 1**
Flow chart of the study participants and inconsistent participation in up to four rounds of fecal immunochemical test (FIT) colorectal cancer screening and response to the lifestyle questionnaire (LSQ) at baseline in the lifestyle sub-study of the bowel cancer screening in Norway: a pilot study. Positive FIT = +FIT. Negative FIT = -FIT. ^a excluded due to dead, moved out of the area, previous colorectal cancer at baseline. ^b Not eligible for invitation for next round of FIT due to age ≥ 75, colorectal cancer diagnosis between FIT rounds, moved outside the county invited for screening, dead

See this image and copyright information in PMC

References

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Lifestyle predictors for inconsistent participation to fecal based colorectal cancer screening

Affiliations

Lifestyle predictors for inconsistent participation to fecal based colorectal cancer screening

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical