Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Mar;36(1):203-218.
doi: 10.1016/j.idc.2021.11.003.

Diagnostic Stewardship in the Pediatric Intensive Care Unit

Affiliations
Review

Diagnostic Stewardship in the Pediatric Intensive Care Unit

Anna C Sick-Samuels et al. Infect Dis Clin North Am. 2022 Mar.

Abstract

In the pediatric intensive care unit (PICU), clinicians encounter complex decision making, balancing the need to treat infections promptly against the potential harms of antibiotics. Diagnostic stewardship is an approach to optimize microbiology diagnostic test practices to reduce unnecessary antibiotic treatment. We review the evidence for diagnostic stewardship of blood, endotracheal, and urine cultures in the PICU. Clinicians should consider 3 questions applying diagnostic stewardship: (1) Does the patient have signs or symptoms of an infectious process? (2) What is the optimal diagnostic test available to evaluate for this infection? (3) How should the diagnostic specimen be collected to optimize results?

Keywords: Diagnostic stewardship; Pediatric intensive care; Sepsis; Urinary tract infection; Ventilator-associated infection.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors have no financial or commercial disclosures.

Figures

Figure 1.
Figure 1.
Diagnostic stewardship supplements antibiotic stewardship to optimize patient management of infectious processes.
Figure 2.
Figure 2.
Applying three steps of clinical diagnostic stewardship when assessing for bacterial infections commonly considered in the Pediatric Intensive Care Unit (PICU).

Similar articles

Cited by

References

    1. World Health Organization. Diagnostic stewardship: a guide to implementation in antimicrobial resistance surveillance sites. 2016; 27. Available at: https://www.who.int/glass/resources/publications/diagnostic-stewardship-.... Accessed May 21, 2021.
    1. World Health Organization. Global Antimicrobial Resistance Surveillance System: Manual for Early Implementation. 2015; http://www.who.int/antimicrobial-resistance/publications/surveillance-sy.... Accessed May 21, 2021.
    1. Morgan DJ, Malani P, Diekema DJ. Diagnostic Stewardship-Leveraging the Laboratory to Improve Antimicrobial Use. Jama. 2017;318(7):607–608. - PubMed
    1. Kenaa B, Richert ME, Claeys KC, et al. Ventilator-Associated Pneumonia: Diagnostic Test Stewardship and Relevance of Culturing Practices. Curr Infect Dis Rep. 2019;21(12):50. - PubMed
    1. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States, 2019. Atlanta, GA: U.S. Department of Health and Human Services;2019.

Substances