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. 2022 Jul;81(7):1045-1048.
doi: 10.1136/annrheumdis-2022-222232. Epub 2022 Feb 15.

Rheumatoid arthritis disease activity assessed by patient-reported outcomes and flow cytometry before and after an additional dose of COVID-19 vaccine

Sara K Tedeschi  1   2 , Jacklyn Stratton  3 , Jack Elias Ellrodt  3 , Mary Grace Whelan  3 , Keigo Hayashi  3 , Kazuki Yoshida  3   2 , Lin Chen  3 , Ifeoluwakiisi Adejoorin  3 , Kathryne Elizabeth Marks  3   2 , A Helena Jonsson  3 , Deepak A Rao  3   2 , Daniel H Solomon  3   2
Affiliations

Rheumatoid arthritis disease activity assessed by patient-reported outcomes and flow cytometry before and after an additional dose of COVID-19 vaccine

Sara K Tedeschi et al. Ann Rheum Dis. 2022 Jul.
No abstract available

Keywords: COVID-19; T-lymphocyte subsets; antirheumatic agents; arthritis; rheumatoid; vaccination.

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Conflict of interest statement

Competing interests: ModernaTx provided support for this investigator-sponsored study (PI: DHS) with payments made directly to Brigham and Women’s Hospital. SKT: research support to Brigham and Women’s Hospital from NIH; consulting fees from NGM Biopharmaceuticals. KY: research support to Brigham and Women’s Hospital from NIH; consulting fees from OM1, Inc. AHJ: research support to Brigham and Women’s Hospital from Amgen. DAR: research support to Brigham and Women’s Hospital from Doris Duke Charitable Foundation, Jansen, Merck, NIH; scientific advisory board member for Bristol Myers Squibb; patent submitted on T peripheral helper cells as a biomarker in autoimmune disease; consulting fees from Jansen. DHS: research support to Brigham and Women’s Hospital from ModernaTx, Amgen, Abbvie, CorEvitas, and NIH; royalties from UpToDate for a chapter related to NSAIDs.

Figures

Figure 1.
Figure 1.. RA disease activity and lymphocyte subsets among subjects that held at least 1 DMARD (top panels) and those that continued all DMARDs (bottom panels) around the time of the additional dose of COVID-19 vaccine.
A) Box-and-whisker plots for RADAI-5 (Rheumatoid Arthritis Disease Activity Index-5) indicate the median (line), mean (diamond), 25th percentile (bottom of box), 75th percentile (top of box), and minimum and maximum values (whiskers). B) Lymphocyte populations were gated as follows: Tph (CD4+ PD-1hi CXCR5−), Tfh (CD4+ PD-1hi CXCR5−), ABCs (CD19+ CD21− CD11C+), plasmablasts (CD19+ CD27hi CD38hi). Patients treated with rituximab (n=3) were included in T cell analyses but excluded from B cell analyses. Summary data on each panel include median (IQR) % lymphocyte population pre- and post-additional dose. Significance testing of flow cytometry data used Wilcoxon paired tests with Bonferroni correction for multiple testing. All comparisons of pre- vs. post- were non-significant (p>0.0125).
See this image and copyright information in PMC

References

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