Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Feb 15;12(1):2471.
doi: 10.1038/s41598-022-06165-z.

Home-based, supervised, and mixed exercise intervention on functional capacity and quality of life of colorectal cancer patients: a meta-analysis

Mauricio Beitia Kraemer  1 , Denise Gonçalves Priolli  1 , Ivan Gustavo Masseli Reis  1 , Andrea Corazzi Pelosi  1 , Ana Luíza Paula Garbuio  1 , Leonardo Henrique Dalcheco Messias  2
Affiliations
Meta-Analysis

Home-based, supervised, and mixed exercise intervention on functional capacity and quality of life of colorectal cancer patients: a meta-analysis

Mauricio Beitia Kraemer et al. Sci Rep. .

Abstract

This systematic review and meta-analysis of randomized controlled trials tested the effects of home-based, supervised, or mixed exercise interventions on the functional capacity (FC) and quality of life (QoL) in colorectal cancer patients. A literature search was performed using the PubMed, Embase, Cochrane, and Medline databases. Two reviewers screened the literature through March 10, 2021 for studies related to exercise and colorectal cancer. Of the 1161 screened studies in the initial search, 13 studies met the eligibility criteria (home-based = 6 studies; supervised or mixed = 7 studies). Overall, 706 patients were enrolled in the trials, and 372 patients were submitted to home-based, supervised, or mixed exercise intervention. The overall results from the main meta-analysis showed a significant effect regarding supervised or mixed intervention (6 studies; p = 0.002; I2 = 43%; PI 0.41-1.39); however, no significant effect was observed for home-based intervention (5 studies; p = 0.05; I2 = 25%; PI - 0.34-0.76). A sensitivity analysis based on studies with intervention adherence ≥ 80% (home-based = 3 studies; supervised or mixed = 4 studies) revealed that home-based intervention or intervention entirely supervised or with some level of supervision (mixed) are effective in improving the QoL and FC of CRC patients. In summary, this meta-analysis verified that supervised and home-based exercise can modify QoL and FC when intervention adherence ≥ 80%. Regardless of the supervision characteristics, future RCTs are strongly encouraged to provide a detailed description of the exercise variables in physical interventions for CRC prescription. This perspective will allow a refined exercise prescription for patients with CRC, mainly according to their clinical status.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of the preferred reporting items for systematic reviews and meta-analyses (PRISMA).
Figure 2
Figure 2
Meta-analysis of quality of life (QoL) and functional capacity (FC) measured in randomized controlled trials that conducted home-based exercise intervention for colorectal cancer patients.
Figure 3
Figure 3
Sensitivity analysis of quality of life (QoL) and functional capacity (FC) measured in randomized controlled trials that conducted home-based exercise intervention with ≥ 80% adherence for colorectal cancer patients.
Figure 4
Figure 4
Meta-analysis of quality of life (QoL) and functional capacity (FC) measured in randomized controlled trials that conducted exercise intervention entirely supervised or with some level of supervision (mixed) for colorectal cancer patients.
Figure 5
Figure 5
Meta-analysis of quality of life (QoL) and functional capacity (FC) measured in randomized controlled trials that conducted exercise intervention entirely supervised or with some level of supervision (mixed) with ≥ 80 of adherence for colorectal cancer patients.
See this image and copyright information in PMC

References

    1. Collaborators, G.B.D.C.C. The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol. Hepatol. 2019;4:913–933. - PMC - PubMed
    1. Society, A.C. 2021. www.cancer.org/cancer/colon-rectal-cancer.
    1. Arnold M, et al. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66:683–691. - PubMed
    1. Conti L, Del Corno M, Gessani S. Revisiting the impact of lifestyle on colorectal cancer risk in a gender perspective. Crit. Rev. Oncol. Hematol. 2020;145:102834. - PubMed
    1. Durko L, Malecka-Panas E. Lifestyle modifications and colorectal cancer. Curr. Colorectal. Cancer Rep. 2014;10:45–54. - PMC - PubMed

Publication types