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. 2022 Feb 15;12(1):2546.
doi: 10.1038/s41598-022-06401-6.

Multi-modal 3D imaging of radionuclides using multiple hybrid Compton cameras

Akihisa Omata  1 , Miho Masubuchi  2 , Nanase Koshikawa  2 , Jun Kataoka  2 , Hiroki Kato  3 , Atsushi Toyoshima  4 , Takahiro Teramoto  4 , Kazuhiro Ooe  3 , Yuwei Liu  3 , Keiko Matsunaga  3 , Takashi Kamiya  3 , Tadashi Watabe  3 , Eku Shimosegawa  3 , Jun Hatazawa  3
Affiliations

Multi-modal 3D imaging of radionuclides using multiple hybrid Compton cameras

Akihisa Omata et al. Sci Rep. .

Abstract

For radiological diagnosis and radionuclide therapy, X-ray and gamma-ray imaging technologies are essential. Single-photon emission tomography (SPECT) and positron emission tomography (PET) play essential roles in radiological diagnosis, such as the early detection of tumors. Radionuclide therapy is also rapidly developing with the use of these modalities. Nevertheless, a limited number of radioactive tracers are imaged owing to the limitations of the imaging devices. In a previous study, we developed a hybrid Compton camera that conducts simultaneous Compton and pinhole imaging within a single system. In this study, we developed a system that simultaneously realizes three modalities: Compton, pinhole, and PET imaging in 3D space using multiple hybrid Compton cameras. We achieved the simultaneous imaging of Cs-137 (Compton mode targeting 662 keV), Na-22 (PET mode targeting 511 keV), and Am-241 (pinhole mode targeting 60 keV) within the same field of view. In addition, the imaging of Ga-67 and In-111, which are used in various diagnostic scenarios, was conducted. We also verified that the 3D distribution of the At-211 tracer inside a mouse could be imaged using the pinhole mode.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
(Upper left) Configuration of the multi-angle measurement. (upper right) Energy spectrum obtained via a HCC by using Cs-137, Na-22, and Am-241 sources simultaneously. (lower) Slice of the 3D reconstructed image (right) and the projections of each source (left); green, red, and blue conversions correspond to Cs-137 (662 keV; Compton mode), Na-22 (PET mode), and Am-241 (60 keV; pinhole mode) sources, respectively.
Figure 2
Figure 2
Pinhole (upper left; 93 keV) and Compton (upper right; 300 keV) MLEM images of a bottle with Ga-67 in 3D space. (lower) Compton MLEM images of two bottles with In-111 (245 keV) in 3D space.
Figure 3
Figure 3
2D slices of the 3D reconstructed image (79 keV; pinhole mode) of the mouse with At-211. Each figure shows a 2.3-mm-pitch slice from the dorsal to the ventral side.
Figure 4
Figure 4
Measurement configurations with various thicknesses of water.
Figure 5
Figure 5
2D reconstructed images for different thicknesses of water (upper two rows) and the projection of those images (lower).
Figure 6
Figure 6
(Left) Spectrum obtained with different thicknesses of water. (right) Correlation between the water thickness and ratio of photopeaks.
Figure 7
Figure 7
(Left) Configuration of the hybrid Compton camera (HCC). (right) Schematic of reconstruction in multi-modality: Compton, PET, and pinhole imaging.
See this image and copyright information in PMC

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