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. 2021 Oct;75(5):356-360.
doi: 10.5455/medarh.2021.75.356-360.

Smoking and COVID-19 in ICU Patients

Ilir Tolaj  1 , Nehat Baftiu  2   3 , Lirim Mustafa  4 , Hajrullah Fejza  5
Affiliations

Smoking and COVID-19 in ICU Patients

Ilir Tolaj et al. Med Arch. 2021 Oct.

Abstract

Background: Case studies revealed an astonishingly low number of current among patients suffering from symptomatic COVID-19 compared to general population, leading to the conclusion that smoking/nicotine uptake might have a preventive effect.

Objective: This study aims to show the relation between smoking habits, present and past, and severity and outcome in COVID-19 patients hospitalized in the ICU of the University Hospital in Pristina.

Methods: This paper reports the results of possible association between smoking habits and severity and outcome of COVID-19. Data on smoking habits, present and past, among 73 patients with severe COVID-19 hospitalized at ICU are analysed and presented.

Results: Smokers (active and ex-smokers) in total were 16 (21.9%) cases (P<0.0001); active smokers were 5 (6.8%) cases (P<0.0001), ex-smokers 11 (15.1%) cases (P<0.0001), and non-smokers were 57 (78.1%) of the cases. From 16 cases (21.92%) identified as active smoker and ex-smoker, 8 of them ended with death, and other 8 cases survived; while 40 cases (54.79%) from the non-smoker group died, while 17 cases (23.29%) from this group survived (95% CI: 0.2881 to 1.5430, P=0.3792). Out of 5 (6.85%) cases of active smokers, 3 (4.11%) of them ended with death (95% CI: 0.1692 to 2.6846, P=0.855); while from 11 (15.07%) of ex-smokers, 5 (6.85%) died (95% CI: 0.1995 to 1.6412, P=0.3561). OR for death among smoker group of cases (active and ex-smokers) was 0.4250 (95% CI: 0.1370 to 1.3189, P=0.1386); for active smokers 0.2550 (95% CI: 0.0547 to 1.1892, p=0.0820), and 0.3542 (95% CI: 0.0950 to 1.3199, P=0.1220) for ex-smokers. Data on the influence of smoking on incidence and severity of COVID-19 ICU cases are conflicting.

Conclusion: A protective effect of smoking in COVID-19 should not be inferred.

Keywords: COVID-19; ICU; outcome; smoking.

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References

    1. Wenzl T. Smoking and COVID-19 - A review of studies which motivated unexpected health claims. 2000 Available: https://publications.jrc.ec.europa.eu/repository/handle/JRC121837.
    1. Tsigaris P, Teixeira da Silva JA. Smoking Prevalence COVID-19 in Europe. Brief Report. 2020. Nicotine Tob Res 1646-1649. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337760/ - PMC - PubMed
    1. Shastri MD, Shukla ShD, Chong WCh, KC R, Dua K, Patel RP, Peterson GM, O’Toole RF. Smoking and COVID-19: What we now so far. Respir Med CME. 2021;176:106237. - PMC - PubMed
    1. Grundy EJ, Suddek T, Suddek T, Filippidis FT, Majeed A, Coronini-Cronberg S. Smoking, SARS-CoV-2 and COVID-19: A review of reviews considering implications for public health policy and practice. Tob Induc Dis. 2020;18(July):58. Available: http://www.tobaccoinduceddiseases.org/Smoking-SARS-CoV-2-and-COVID-19-A-.... - PMC - PubMed
    1. Reddy RK, Charles WN, Sklavounos A, Dutt A, Seed PT, Khajuria A. (2020). The effect of smoking on COVID-19 severity: A systematic review and meta-analysis. J Med Virol 1-12. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436545/ - PMC - PubMed