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. 2022 Jun 15;225(12):2229-2234.
doi: 10.1093/infdis/jiac054.

Impact of Latent Tuberculosis on Diabetes

Burcu Tepekule  1   2 , Katharina Kusejko  1   2 , Marius Zeeb  1   2 , Philip E Tarr  3 , Alexandra Calmy  4 , Manuel Battegay  5 , Hansjakob Furrer  6 , Matthias Cavassini  7 , Enos Bernasconi  8 , Julia Notter  9 , Huldrych F Günthard  1 , Johannes Nemeth  1 , Roger D Kouyos  1   2 ; Swiss HIV Cohort Study
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Free article

Impact of Latent Tuberculosis on Diabetes

Burcu Tepekule et al. J Infect Dis. .
Free article

Abstract

While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV in the Swiss HIV Cohort Study via time-dependent Cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR = 1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.

Keywords: heterologous immunity; inflammatory diseases; innate immunity; latent tuberculosis; low-grade inflammation; type-2 diabetes mellitus.

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