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Review
. 2022 Feb 16;43(3):373-378.
doi: 10.1515/hmbci-2021-0081. eCollection 2022 Sep 1.

COVID-19 infection in pregnancy: a review of existing knowledge

Swayam Swaroop Misra  1 , Ashok Kumar Ahirwar  2 , Apurva Sakarde  3 , Kirti Kaim  4 , Pradeep Ahirwar  5 , Mohd Jahid  2 , Smita R Sorte  6 , Suryabhan Lahanu Lokhande  7 , Amar Preet Kaur  8 , Rajani Kumawat  9
Affiliations
Free article
Review

COVID-19 infection in pregnancy: a review of existing knowledge

Swayam Swaroop Misra et al. Horm Mol Biol Clin Investig. .
Free article

Abstract

The world has been coping up with the grave pandemic of COVID-19 since its inception into the human race in December, 2019. By entering the host through the spike (S) glycoprotein, it paves way for its own survival and multiplication. Respiratory tract being the point of entry causes pulmonary compromise and leads to development of ARDS. Having non-specific clinical features that resemble flu makes the clinical diagnosis much more difficult. Pregnancy being an immunocompromised and a hypercoagulable state is prone to be a high-risk group for COVID-19. This study is an attempt to understand the maternal and fetal outcomes in COVID-19 and the vertical transmissibility of the virus. Evidence suggests that the contribution of COVID-19 is not very significant in maternal morbidity and mortality. However, due to some factors such as the immunological response in the mother, certain complications may arise in the neonate in the post-natal period. No vertical transmission of the virus has been reported yet. However, the management remains crucial as two lives are at stake. Some of the precautionary measures that can be implemented to prevent COVID-19 can be segregation of medical services from that of the general population in settings of outpatient care, inpatient care and labor room care. Also, triaging the patients into low risk, moderate risk and high risk can aid in faster delivery of health-care facilities to the pregnant and the newborn.

Keywords: COVID-19; SARS-CoV-2; complications; delivery; fetus; pregnancy.

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