Outstanding outcomes in infants with KMT2A-germline acute lymphoblastic leukemia treated with chemotherapy alone: results of the Children's Oncology Group AALL0631 trial

Affiliations

¹ Division of Hematology/Oncology/Blood and Marrow Transplantation, Children's Mercy Kansas City, Kansas City, MO. eguest@cmh.edu.
² Department of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, FL.
³ Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO.
⁴ Texas Children's Hospital, Houston, TX.
⁵ Department of Genetics, University of Alabama at Birmingham, Birmingham, AL.
⁶ The Ohio State University Comprehensive Cancer Center, Columbus, OH.
⁷ Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN.
⁸ U.S. Army Medical Research and Materiel Command, Fort Detrick, MD.
⁹ Division of Pediatric Hematology/Oncology, University of Texas Southwestern School of Medicine, Dallas, TX.
¹⁰ Department of Pediatrics and Perlmutter Cancer Center, NYU Langone Health, New York, NY.
¹¹ Departments of Pathology and Oncology, Johns Hopkins University, Baltimore, MD.
¹² Department of Pediatrics, Benioff Children's Hospital in the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
¹³ Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
¹⁴ Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD.

Clinical Trial

Erin M Guest et al. Haematologica. 2022.

. 2022 May 1;107(5):1205-1208.

doi: 10.3324/haematol.2021.280146.

¹ Division of Hematology/Oncology/Blood and Marrow Transplantation, Children's Mercy Kansas City, Kansas City, MO. eguest@cmh.edu.
² Department of Biostatistics, Colleges of Medicine, Public Health and Health Professions, University of Florida, Gainesville, FL.
³ Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO.
⁴ Texas Children's Hospital, Houston, TX.
⁵ Department of Genetics, University of Alabama at Birmingham, Birmingham, AL.
⁶ The Ohio State University Comprehensive Cancer Center, Columbus, OH.
⁷ Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN.
⁸ U.S. Army Medical Research and Materiel Command, Fort Detrick, MD.
⁹ Division of Pediatric Hematology/Oncology, University of Texas Southwestern School of Medicine, Dallas, TX.
¹⁰ Department of Pediatrics and Perlmutter Cancer Center, NYU Langone Health, New York, NY.
¹¹ Departments of Pathology and Oncology, Johns Hopkins University, Baltimore, MD.
¹² Department of Pediatrics, Benioff Children's Hospital in the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
¹³ Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
¹⁴ Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD.

No abstract available

Figures

1. Dreyer ZE, Hilden JM, Jones TL, et al. . Intensified chemotherapy without SCT in infant ALL: results from COG P9407 (Cohort 3). Pediatr Blood Cancer. 2015;62(3):419-426. - PMC - PubMed
1. Pieters R, De Lorenzo P, Ancliffe P, et al. . Outcome of infants younger than 1 year with acute lymphoblastic leukemia treated with the Interfant-06 protocol: results from an international phase III randomized study. J Clin Oncol. 2019;37(25):2246-2256. - PubMed
1. Pieters R, Schrappe M, De Lorenzo P, et al. . A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet. 2007;370(9583):240-250. - PubMed
1. Hilden JM, Dinndorf PA, Meerbaum SO, et al. . Analysis of prognostic factors of acute lymphoblastic leukemia in infants: report on CCG 1953 from the Children's Oncology Group. Blood. 2006;108(2):441-451. - PMC - PubMed
1. Tomizawa D, Miyamura T, Imamura T, et al. . A risk-stratified therapy for infants with acute lymphoblastic leukemia: a report from the JPLSG MLL-10 trial. Blood. 2020;136(16):1813-1823. - PubMed