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. 2022 Feb 16;22(1):131.
doi: 10.1186/s12884-022-04465-w.

Pregnancy complications and risk of uterine rupture among women with singleton pregnancies in China

Jing Tao  1 , Yi Mu  1 , Peiran Chen  1 , Yanxia Xie  1 , Juan Liang  2 , Jun Zhu  3   4
Affiliations

Pregnancy complications and risk of uterine rupture among women with singleton pregnancies in China

Jing Tao et al. BMC Pregnancy Childbirth. .

Abstract

Background: The goal of this study was to investigate whether pregnancy complications are associated with an increased risk of uterine rupture (UR) and how that risk changes with gestational age.

Methods: We obtained all data from China's National Maternal Near Miss Surveillance System (NMNMSS) between 2012 and 2018. Poisson regression analysis was used to assess the risk of UR with pregnancy complications (preeclampsia, gestational diabetes mellitus, placental abruption, placenta previa and placenta percreta) among 9,454,239 pregnant women. Furthermore, we analysed the risks of UR with pregnancy complications in different gestational age groups.

Results: The risk of UR was increased 2.0-fold (1.2-fold to 2.7-fold) in women with pregnancy complications (except for preeclampsia). These associations also persisted in women without a previous caesarean delivery. Moreover, an increased risk of UR before term birth was observed among women with gestational diabetes mellitus, placental abruption and placenta percreta. The risk of UR was slightly higher in women with gestational diabetes mellitus who had a large for gestational age (LGA) foetus, especially at 32 to 36 weeks gestation.

Conclusions: The risk of UR is associated with gestational diabetes mellitus, placental abruption, placenta previa and placenta percreta, but varies in different gestational ages.

Keywords: Large for gestational age; Pregnancy complications; Preterm delivery; Risk factors; Uterine rupture.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Type and percent of observed pregnancy complications among 875,245 pregnant women. Note: We did show more than 0.3% of observed combinations of pregnancy complications among 885,087 pregnant women. Less than 1% of observed combinations of pregnancy complications were not labelled. GD: Gestational diabetes, PE: Preeclampsia, PP: Placenta praevia, PA: Placental abruption, PPE: Placenta percreta
Fig. 2
Fig. 2
Uterine rupture rate and the ratio of women with pregnancy complications, China, 2012–2018. Note: The UR rate was weighted for the sampling distribution of the population covered by the Chinese National Maternal Near Miss Surveillance System. The UR rate was the number of pregnant women with UR per 1,000 pregnant women. Ratio of women with pregnancy complications was the ratio of women with pregnancy complications to all women
See this image and copyright information in PMC

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