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. 2022 Feb 16;23(1):154.
doi: 10.1186/s12891-022-05105-2.

Influence of type I collagen polymorphisms and risk of anterior cruciate ligament rupture in athletes: a case-control study

Jamila Alessandra Perini  1   2   3 , Lucas Rafael Lopes  4   5 , João Antonio Matheus Guimarães  6 , Rodrigo Araújo Goes  7 , Luiz Fernando Alves Pereira  6 , Camili Gomes Pereira  6   4 , Marcelo Mandarino  8 , Alfredo Marques Villardi  8 , Eduardo Branco de Sousa  8 , Victor Rodrigues Amaral Cossich  6
Affiliations

Influence of type I collagen polymorphisms and risk of anterior cruciate ligament rupture in athletes: a case-control study

Jamila Alessandra Perini et al. BMC Musculoskelet Disord. .

Abstract

Background: Anterior cruciate ligament (ACL) rupture is a common and severe knee injury in sports and occurs mostly due to noncontact injuries. There is an increasing amount of evidence associating ACL rupture to single nucleotide polymorphisms (SNPs), and SNPs in the collagen type I genes can change its expression and tissue mechanical features. This study aimed to investigate the association between SNPs in COL1A1 and COL1A2 with sports-related ACL tears.

Methods: A total of 338 athletes from multiple sports modalities were analyzed: 146 were diagnosed with ACL rupture or underwent an ACL reconstruction surgery and 192 have no musculoskeletal injuries. SNPs were genotyped using validated TaqMan assays. The association of the polymorphisms with ACL rupture was evaluated by a multivariable logistic regression model, using odds ratios (OR) and 95% confidence intervals (CI).

Results: The age, sport modality, and training location were associated with an increased risk of a non-contact ACL tear. COL1A2 SNPs (rs42524 CC and rs2621215 GG) were associated with an increased risk of non-contact ACL injury (6 and 4-fold, respectively). However, no significant differences were detected in the distribution of COL1A1 rs1107946 and COL1A2 rs412777 SNPs between cases and controls. There was a protective association with ACL rupture (OR = 0.25; 95% CI = 0.07-0.96) between COL1A1 rs1107946 (GT or TT) and the wildtype genotypes of the three COL1A2 (rs412777, rs42524, rs2621215). COL1A2 rs42524 and rs2621215 SNPs were associated with non-contact ACL risk.

Conclusion: The combined analysis of COL1A1-COL1A2 genotypes suggests a gene-gene interaction in ACL rupture susceptibility.

Keywords: ACL rupture; Athletes; Collagen; Polymorphisms.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Haplotype analysis for COL1A2 (rs412777, rs42524, rs2621215) SNPs in Brazilian athletes. A. Number in boxes indicates decimal places of D′. B. Haplotype distributions between injured group and non-contact ACL injury compared to control group
See this image and copyright information in PMC

References

    1. Kim S, Akaike T, Sasagaw T, Atomi Y, Kurosawa H. Gene expression of type I and type III collagen by mechanical stretch in anterior cruciate ligament cells. Cell Struct Funct. 2002;27(3):139–144. - PubMed
    1. Hsu S, Liang R, Woo S. Functional tissue engineering of ligament healing. Sports Med Arthrosc Rehabil Ther Technol. 2010;2(1):21. - PMC - PubMed
    1. Kiapour A, Murray M. Basic science of anterior cruciate ligament injury and repair. Bone Joint Res. 2014;3(2):20–31. - PMC - PubMed
    1. Nguyen D, Ramwadhdoebe T, van der Hart C, Blankevoort L, Tak P, van Dijk C. Intrinsic healing response of the human anterior cruciate ligament: an histological study of reattached ACL remnants. J Orthop Res. 2014;32(2):296–301. - PubMed
    1. Matsumoto H, Suda Y, Otani T, Niki Y, Seedhom B, Fujikawa K. Roles of the anterior cruciate ligament and the medial collateral ligament in preventing valgus instability. J Orthop Sci. 2001;6(1):28–32. - PubMed

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